Evidence for familial aggregation in siblings with autoimmune rheumatic diseases

Autoimmune rheumatic disorders have a multifactorial determinism, caused by various environmental factors acting on the individual’s genetic susceptibility, destabilizing the systems which regulate the immune response. Epidemiological and genetic investigations are very important to demonstrate the...

Full description

Saved in:
Bibliographic Details
Published in:Revista română de reumatologie 2018-03, Vol.27 (1), p.19-22
Main Authors: Duna, Madalina-Pusa, Predeteanu, Denisa, Berghea, F., Abobului, M., Vlad, Violeta, Balanescu, Andra, Opris-Belinski, Daniela, Bojinca, Violeta, Constantinescu, C.L., Borangiu, Andreea, Groseanu, Laura, Saulescu, Ioana, Negru, Maria-Magdalena, Cobilinschi, Claudia, Daia, Sanziana, Mazilu, Diana, Ionescu, Ruxandra
Format: Article
Language:English
Subjects:
autoimmune disorders
familial aggregation
siblings
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autoimmune rheumatic disorders have a multifactorial determinism, caused by various environmental factors acting on the individual’s genetic susceptibility, destabilizing the systems which regulate the immune response. Epidemiological and genetic investigations are very important to demonstrate the contribution of genetic factors to the development of these autoimmune diseases. The contribution of genetic factors in causing autoimmune diseases has been demonstrated by familial aggregation. Moreover, it was also quantified by determining heritability, expressing the proportion of genetic factors in the etiology. It is now clear that common genes underlie multiple autoimmune disorders.
ISSN:1843-0791
2069-6086
DOI:10.37897/RJR.2018.1.3