An increase of phosphatidylcholines in follicular fluid implies attenuation of embryo quality on day 3 post-fertilization

Although oocyte quality is the dominant factor determining embryo quality, few studies have been conducted to evaluate embryo quality based on the metabolites related to the oocyte. With quantification of the follicular fluid (FF) metabolites, in assisted reproductive technology (ART), this study so...

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Bibliographic Details
Published in:BMC biology 2021-09, Vol.19 (1), p.200-200, Article 200
Main Authors: Wang, Ju, Zheng, Wei, Zhang, Shuoping, Yan, Keqiang, Jin, Miao, Hu, Huiling, Ma, Zhen, Gong, Fei, Lu, Guangxiu, Ren, Yan, Lin, Liang, Lin, Ge, Hu, Liang, Liu, Siqi
Format: Article
Language:English
Subjects:
Arachidonic acid
Assisted reproductive technology
Attenuation
Biomarkers
Clinical medicine
Embryo quality
Embryonic Development
Embryos
Evaluation
Female
Fertilization
Fertilization in Vitro
Follicular Fluid
Gametocytes
Humans
In vitro fertilization
Influence
Lecithin
Mass spectrometry
Metabolites
Oocyte quality
Oocytes
Phosphatidylcholines
Quality management
Random forest
Reproductive technologies
Reproductive technology
Retention
Scientific imaging
Targeted metabolomics
Uterus
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Summary:Although oocyte quality is the dominant factor determining embryo quality, few studies have been conducted to evaluate embryo quality based on the metabolites related to the oocyte. With quantification of the follicular fluid (FF) metabolites, in assisted reproductive technology (ART), this study sought to evaluate the embryo or oocyte quality through an informative approach. An evaluation model consisting of 17 features was generated to distinguish the embryo quality on day 3 post-fertilization, and phosphatidylcholines (PCs) were the key contributors to the evaluation. The model was extended to the patients under different ages and hyperstimulations, and the features were further enriched to facilitate the evaluation of the embryo quality. The metabolites were clustered through pathway analysis, leading to a hypothesis that accumulation of arachidonic acid induced by PCs might weaken embryo quality on day 3 post-fertilization. A discriminating model with metabolic features elicited from follicular fluid was established, which enabled the evaluation of the embryo or oocyte quality even under certain clinical conditions, and the increase of PCs in follicular fluid implies the attenuation of embryo quality on day 3 post-fertilization.
ISSN:1741-7007
1741-7007
DOI:10.1186/s12915-021-01118-w