Unexpected distribution of KRIT1 inside the nucleus: new insight in a complex molecular pathway

KRIT1 is an 84kDa protein that lacks any relevant catalytic domains, associated with the cerebral cavernous malformation disease. We have investigated by means of ultrastructural immunocytochemistry the nuclear distribution of KRIT1 in different cell lines, revealing its unexpected localization on a...

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Bibliographic Details
Published in:European journal of histochemistry 2014-03, Vol.58 (1), p.2358-2358
Main Authors: Marzo, S, Galimberti, V, Biggiogera, M
Format: Article
Language:English
Subjects:
Brief Report
Cell Nucleus - metabolism
cell nucleus, cerebral cavernous malformations, KRIT1, transcription, electron microscopy, immunocytochemistry
HeLa Cells
Humans
KRIT1 Protein
Microtubule-Associated Proteins - metabolism
Nuclear Proteins - metabolism
Proto-Oncogene Proteins - metabolism
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Description
Summary:KRIT1 is an 84kDa protein that lacks any relevant catalytic domains, associated with the cerebral cavernous malformation disease. We have investigated by means of ultrastructural immunocytochemistry the nuclear distribution of KRIT1 in different cell lines, revealing its unexpected localization on actively transcribing nuclear domains such as the perichromatin fibrils and the nucleolar dense fibrillar component. These preliminary data indicate a still undescribed and unknown role for KRIT1 inside the nucleus.
ISSN:1121-760X
2038-8306
DOI:10.4081/ejh.2014.2358