Ternary Ti alloys functionalised with antibacterial activity

Prosthesis bacterial infection occurring during surgery is a rising health issue. Pathogenic bacterial infection causes inflammation, interferes with the healing process, inhibits osteogenesis and, eventually, leads to implant failure. These issues can be tackled either by applying coatings or devel...

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Bibliographic Details
Published in:Scientific reports 2020-12, Vol.10 (1), p.22201-22201, Article 22201
Main Authors: Bolzoni, L., Alqattan, M., Peters, L., Alshammari, Y., Yang, F.
Format: Article
Language:English
Subjects:
639/166/985
639/301/54
Alloys
Alloys - chemistry
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Bacterial diseases
Bacterial infections
Biocompatible Materials - chemistry
Chemical Phenomena
E coli
Escherichia coli - drug effects
Humanities and Social Sciences
Mechanical Phenomena
Mechanical properties
Metallurgy
Microbial Sensitivity Tests
multidisciplinary
Osteogenesis
Powder metallurgy
Prosthetics
Science
Science (multidisciplinary)
Surgery
Titanium - chemistry
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Summary:Prosthesis bacterial infection occurring during surgery is a rising health issue. Pathogenic bacterial infection causes inflammation, interferes with the healing process, inhibits osteogenesis and, eventually, leads to implant failure. These issues can be tackled either by applying coatings or developing multifunctional (i.e. structural and antibacterial) materials. In this work, β eutectoid bearing functionalised Ti alloys were designed and manufactured via the cost-effective press and sinter powder metallurgy route. The systematic analysis of the ternary Ti–xCu–yMn alloys shows that the mechanical properties proportionally increase with the amount of alloying elements added. All the ternary Ti–xCu–yMn alloys have strong antibacterial activity against Escherichia coli with respect to the negative control (i.e. pure Ti). Our study demonstrates that ternary Ti–xCu–yMn alloys are promising candidates for structural prostheses functionalised with antibacterial capability.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-79192-3