Supramolecular Complexation of Carbohydrates for the Bioavailability Enhancement of Poorly Soluble Drugs

In this review, a comprehensive overview of advances in the supramolecular complexes of carbohydrates and poorly soluble drugs is presented. Through the complexation process, poorly soluble drugs could be efficiently delivered to their desired destinations. Carbohydrates, the most abundant biomolecu...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2015-10, Vol.20 (10), p.19620-19646
Main Authors: Cho, Eunae, Jung, Seunho
Format: Article
Language:English
Subjects:
bioavailability enhancement
Biological Availability
carbohydrates
Carbohydrates - chemistry
Drug Compounding
Drug Stability
Excipients - chemistry
Hydrophobic and Hydrophilic Interactions
Pharmaceutical Preparations - chemistry
Pharmacokinetics
poorly soluble drugs
Review
Solubility
supramolecular complexation
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Summary:In this review, a comprehensive overview of advances in the supramolecular complexes of carbohydrates and poorly soluble drugs is presented. Through the complexation process, poorly soluble drugs could be efficiently delivered to their desired destinations. Carbohydrates, the most abundant biomolecules, have diverse physicochemical properties owing to their inherent three-dimensional structures, hydrogen bonding, and molecular recognition abilities. In this regard, oligosaccharides and their derivatives have been utilized for the bioavailability enhancement of hydrophobic drugs via increasing the solubility or stability. By extension, polysaccharides and their derivatives can form self-assembled architectures with poorly soluble drugs and have shown increased bioavailability in terms of the sustained or controlled drug release. These supramolecular systems using carbohydrate will be developed consistently in the field of pharmaceutical and medical application.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules201019620