2 year followup of patients with diabetes mellitus nephropathy showing albuminuria reversal following angiotensin converting enzyme inhibitors

Two-year follow-up of patients with diabetes mellitus (DM) nephropathy shows albuminuria reversal following angiotensin converting enzyme (ACE) inhibitors. To study about a clinical profile of 2-year follow-up of patients with DM nephropathy showing albuminuria reversal following ACE inhibitors. Twe...

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Bibliographic Details
Published in:Indian journal of endocrinology and metabolism 2012-12, Vol.16 (Suppl 2), p.S447-S449
Main Authors: Gopinath, S, Ganesh, B Amirtha, Manoj, K, Rubiya
Format: Article
Language:English
Subjects:
ACE inhibitors
albumin reversal
Albuminuria
angiotensin converting enzyme inhibitors
Brief Communication
Care and treatment
Diabetes mellitus nephropathy
Diabetics
Diseases
Drug therapy
Health aspects
Prognosis
Risk factors
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Summary:Two-year follow-up of patients with diabetes mellitus (DM) nephropathy shows albuminuria reversal following angiotensin converting enzyme (ACE) inhibitors. To study about a clinical profile of 2-year follow-up of patients with DM nephropathy showing albuminuria reversal following ACE inhibitors. Twenty patients were taken up for study with duly informed consent and suggested for glycemic profile with HbA1C. Baseline renal function, urine microscopy, albuminuria, and other microvascular complications such as neuropathy and retinopathy. These patients were followed up for a period of 2 years with every month follow-up and monthly dose titration of ACE inhibitors, enalapril (Quote: Dr. M. K. Mani), to a maximum tolerable dose and checked after 1 week for raise in creatinine and potassium. Twenty patients, who have attended a secondary level diabetic clinic with diabetic nephropathy and are on regular follow-up for 2 years, were selected. Sick patients requiring parenteral feeds, IV antibiotics, co-morbid conditions such as autonomic gastroparesis and diabetic foot infections, type 1 diabetes and other known kidney disease, chronic kidney disease on dialysis are excluded from the study. EXPECTED RESULT: Reversal of albuminuria. Enalapril is a safe, cheaper ACE inhibitors and the good dose titration coupled with early screening for DM nephropathy really help in halting the progression of chronic kidney disease from DM nephropathy.
ISSN:2230-8210
2230-9500
DOI:10.4103/2230-8210.104127