Manifestations and Outcome of Cardiac Sarcoidosis and Idiopathic Giant Cell Myocarditis by 25-Year Nationwide Cohorts

Background Cardiac sarcoidosis (CS) and giant cell myocarditis (GCM) share many histopathologic and clinical features. Whether they are parts of a one-disease continuum has been discussed. Methods and Results We compared medical record data of 351 CS and 28 GCM cases diagnosed in Finland since the l...

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Published in:Journal of the American Heart Association 2021-03, Vol.10 (6), p.e019415-e019415
Main Authors: Nordenswan, Hanna-Kaisa, Lehtonen, Jukka, Ekström, Kaj, Räisänen-Sokolowski, Anne, Mäyränpää, Mikko I, Vihinen, Tapani, Miettinen, Heikki, Kaikkonen, Kari, Haataja, Petri, Kerola, Tuomas, Rissanen, Tuomas T, Kokkonen, Jorma, Alatalo, Aleksi, Pietilä-Effati, Päivi, Utriainen, Seppo, Kupari, Markku
Format: Article
Language:English
Subjects:
cardiac sarcoidosis
giant cell myocarditis
inflammatory heart disease
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Summary:Background Cardiac sarcoidosis (CS) and giant cell myocarditis (GCM) share many histopathologic and clinical features. Whether they are parts of a one-disease continuum has been discussed. Methods and Results We compared medical record data of 351 CS and 28 GCM cases diagnosed in Finland since the late 1980s and followed until February 2018 for a composite end point of cardiac death, aborted sudden death, and heart transplantation. Heart failure was the presenting manifestation in 50% versus 15% (
ISSN:2047-9980
2047-9980
DOI:10.1161/jaha.120.019415