Screening for oncogenic AF1q expression predicts disease recurrence in gastric cancer patients

AF1q associates with tumor progression and metastases upon WNT signaling. The downstream WNT target CD44 has demonstrated prognostic significance in gastric cancer (GC). This study evaluates the impact of AF1q on tumor stage and survival in GC patients. Immunohistochemical marker expression was anal...

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Bibliographic Details
Published in:Scientific reports 2024-07, Vol.14 (1), p.15988-8, Article 15988
Main Authors: Gruber, Elisabeth S., Oberhuber, Georg, Schlederer, Michaela, Birner, Peter, Jomrich, Gerd, Schoppmann, Sebastian F., Tse, William, Kenner, Lukas
Format: Article
Language:English
Subjects:
692/4020/1503/1504/1829
692/4028/546
Adult
AF1q
Aged
Biomarkers, Tumor - metabolism
CD44
CD44 antigen
Female
Gastric cancer
Gene Expression Regulation, Neoplastic
Humanities and Social Sciences
Humans
Hyaluronan Receptors - genetics
Hyaluronan Receptors - metabolism
Lymph node stage
Lymph nodes
Male
Medical prognosis
Metastases
Middle Aged
multidisciplinary
Neoplasm Recurrence, Local - metabolism
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Patients
Prognosis
Recurrence
Science
Science (multidisciplinary)
Stomach Neoplasms - diagnosis
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Survival
Survival analysis
Tumors
Wnt protein
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Description
Summary:AF1q associates with tumor progression and metastases upon WNT signaling. The downstream WNT target CD44 has demonstrated prognostic significance in gastric cancer (GC). This study evaluates the impact of AF1q on tumor stage and survival in GC patients. Immunohistochemical marker expression was analyzed and data were processed to correlation and survival analysis. Out of 182 GC samples, 178 (97.8%) showed moderate to high AF1q expression ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-67058-x