The Aerogen ® Solo Is an Alternative to the Small Particle Aerosol Generator (SPAG-2) for Administration of Inhaled Ribavirin

Respiratory syncytial virus (RSV) is associated with adverse outcomes among immunocompromised patients. Inhaled ribavirin has been shown to improve mortality rates. The Small-Particle Aerosol Generator delivery system (SPAG-2) is the only FDA-cleared device to deliver inhaled ribavirin. However, it...

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Bibliographic Details
Published in:Pharmaceutics 2020-11, Vol.12 (12), p.1163
Main Authors: Dallas, Ronald H, Rains, Jason K, Wilder, Keith, Humphrey, William, Cross, Shane J, Ghafoor, Saad, Brazelton de Cardenas, Jessica N, Hayden, Randall T, Hijano, Diego R
Format: Article
Language:English
Subjects:
Aerogen® Solo
Aerosols
Biohazards
children
Communication
Drug dosages
Hospitals
infection
Infections
Leukemia
Mortality
Pneumonia
Respiratory syncytial virus
Respiratory therapy
ribavirin
RSV
SPAG-2
Ventilation
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Summary:Respiratory syncytial virus (RSV) is associated with adverse outcomes among immunocompromised patients. Inhaled ribavirin has been shown to improve mortality rates. The Small-Particle Aerosol Generator delivery system (SPAG-2) is the only FDA-cleared device to deliver inhaled ribavirin. However, it is difficult to set up and maintain. We developed a method for delivery of this medication using the vibrating mesh nebulizer (Aerogen ). We did not observe any adverse events with this method.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics12121163