Nanoparticles Targeting the Molecular Pathways of Heart Remodeling and Regeneration

Cardiovascular diseases are the main cause of death worldwide, a trend that will continue to grow over the next decade. The heart consists of a complex cellular network based mainly on cardiomyocytes, but also on endothelial cells, smooth muscle cells, fibroblasts, and pericytes, which closely commu...

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Bibliographic Details
Published in:Pharmaceutics 2022-03, Vol.14 (4), p.711
Main Authors: Gonciar, Diana, Mocan, Teodora, Agoston-Coldea, Lucia
Format: Article
Language:English
Subjects:
cardiomyocytes
Cardiovascular disease
Contrast agents
Drugs
Heart attacks
Iodine
Lipids
Magnetic resonance imaging
Metabolism
Nanoparticles
Polyamines
Polyethylene glycol
regeneration
remodeling
Review
Tomography
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Summary:Cardiovascular diseases are the main cause of death worldwide, a trend that will continue to grow over the next decade. The heart consists of a complex cellular network based mainly on cardiomyocytes, but also on endothelial cells, smooth muscle cells, fibroblasts, and pericytes, which closely communicate through paracrine factors and direct contact. These interactions serve as valuable targets in understanding the phenomenon of heart remodeling and regeneration. The advances in nanomedicine in the controlled delivery of active pharmacological agents are remarkable and may provide substantial contribution to the treatment of heart diseases. This review aims to summarize the main mechanisms involved in cardiac remodeling and regeneration and how they have been applied in nanomedicine.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14040711