Dysfunction of Drosophila mitochondrial carrier homolog (Mtch) alters apoptosis and disturbs development

Mitochondrial carrier homologs 1 (MTCH1) and 2 (MTCH2) are orphan members of the mitochondrial transporter family SLC25. Human MTCH1 is also known as presenilin 1-associated protein, PSAP. MTCH2 is a receptor for tBid and is related to lipid metabolism. Both proteins have been recently described as...

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Bibliographic Details
Published in:FEBS open bio 2024-02, Vol.14 (2), p.276-289
Main Authors: González, Cristina, Martínez-Sánchez, Lidia, Clemente, Paula, Toivonen, Janne Markus, Arredondo, Juan José, Fernández-Moreno, Miguel Ángel, Carrodeguas, José Alberto
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Apoptosis
Apoptosis - genetics
Cell Biology and Development
development
Drosophila
Drosophila - metabolism
Growth factors
Homeostasis
Humans
Insects
Kinases
Lipid metabolism
Lipids
Membrane Proteins - metabolism
Mitochondria
Mitochondria - genetics
Mitochondria - metabolism
mitochondrial carrier homolog (MTCH)
Mitochondrial Membrane Transport Proteins - metabolism
Mitochondrial Proteins - metabolism
Phylogenetics
Presenilin 1
Proteins
Pupation
RNA-mediated interference
Signal transduction
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Summary:Mitochondrial carrier homologs 1 (MTCH1) and 2 (MTCH2) are orphan members of the mitochondrial transporter family SLC25. Human MTCH1 is also known as presenilin 1-associated protein, PSAP. MTCH2 is a receptor for tBid and is related to lipid metabolism. Both proteins have been recently described as protein insertases of the outer mitochondrial membrane. We have depleted Mtch in Drosophila and show here that mutant flies are unable to complete development, showing an excess of apoptosis during pupation; this observation was confirmed by RNAi in Schneider cells. These findings are contrary to what has been described in humans. We discuss the implications in view of recent reports concerning the function of these proteins.
ISSN:2211-5463
2211-5463
DOI:10.1002/2211-5463.13742