Metabolite Profiling and Bioactivities of Leaves, Stems, and Flowers of Rumex usambarensis (Dammer) Dammer, a Traditional African Medicinal Plant

The comprehensive identification of secondary metabolites represents a fundamental step for the assessment of bioactivities and pharmacological properties of traditional herbal drugs. (Dammer) Dammer has been described as a multipurpose remedy in different African traditional pharmacopoeias, but its...

Full description

Saved in:
Bibliographic Details
Published in:Plants (Basel) 2023-01, Vol.12 (3), p.482
Main Authors: Spaggiari, Chiara, Righetti, Laura, Spadini, Costanza, Annunziato, Giannamaria, Nsanzurwimo, Aimable, Cabassi, Clotilde Silvia, Bruni, Renato, Costantino, Gabriele
Format: Article
Language:English
Subjects:
Annotations
Antiinfectives and antibacterials
Antimicrobial agents
Antioxidants
Biological activity
Dammer
Flavonoids
Flowers
Flowers & plants
Herbal medicine
High performance liquid chromatography
Investigations
Ionic mobility
Leaves
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Medicinal plants
Metabolites
Metabolomics
Pharmacology
Phytochemicals
Plants (botany)
Quadrupoles
Rumex
Rumex usambarensis (Dammer)
Scientific imaging
Secondary metabolites
Stems
traditional healers knowledge
Traveling waves
UHPLC-TWINS-QTOF
untargeted metabolomics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The comprehensive identification of secondary metabolites represents a fundamental step for the assessment of bioactivities and pharmacological properties of traditional herbal drugs. (Dammer) Dammer has been described as a multipurpose remedy in different African traditional pharmacopoeias, but its phytochemical profile has not been properly investigated. Herein we report a high throughput metabolomic screening, based on ultra-high performance liquid chromatography-travelling wave ion mobility spectrometry quadrupole time-of-flight (UHPLC-TWINS-QTOF), which was performed for the first time on different plant parts. By applying high-resolution mass spectrometry-based metabolomics and chemometric analysis, a complete discrimination of different aerial parts was obtained, with the annotation of 153 significant metabolites in leaves, stems, and flowers, suggesting an easy authentication and discrimination route. Phytochemical data were correlated to antimicrobial and antioxidant properties. Flavonoids, benzopyranes, chromones, and xanthones derivatives, along with a richer phytocomplex, might be responsible for the stronger bioactivities obtained from flowers.
ISSN:2223-7747
2223-7747
DOI:10.3390/plants12030482