Atypical chronic myeloid leukemia BCR-ABL 1 negative: A case report and literature review

Atypical chronic myeloid leukemia (aCML), BCR-ABL1 negative is a rare myelodysplastic syndrome/myeloproliferative neoplasm for which no current standard of care exists. The blood smear of patients with aCML showed prominent immature granulocytosis, and granulocytic dysplasia. We admitted a 58-year-o...

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Bibliographic Details
Published in:Leukemia research reports 2019-01, Vol.12, p.100172, Article 100172
Main Authors: Belkhair, Jihane, Raissi, Abderahim, Elyahyaoui, Hicham, Ameur, Mustapha Ait, Chakour, Mohamed
Format: Article
Language:English
Subjects:
Atypical chronic myeloid leukemia
BCR-ABL1
Cytology
Karyotype
Molecular biology
Myelodysplastic syndroms/myeloproliferative syndroms
Philadelphia chromosome
World Health Organization
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Summary:Atypical chronic myeloid leukemia (aCML), BCR-ABL1 negative is a rare myelodysplastic syndrome/myeloproliferative neoplasm for which no current standard of care exists. The blood smear of patients with aCML showed prominent immature granulocytosis, and granulocytic dysplasia. We admitted a 58-year-old man with splenomegaly, hyperleukocytosis, anemia, and thrombocytopenia; then cytology, cytogenetic and molecular biology analysis of bone morrow were performed and the diagnosis of aCML was made according to 2016 World Health Organization diagnostic criteria. The patient was initially treated by chemotherapy; the patient achieved an aggravation of anemia. This motivated the change of treatment.
ISSN:2213-0489
2213-0489
DOI:10.1016/j.lrr.2019.100172