Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle

Both glucose and free fatty acids (FFAs) are used as fuel sources for energy production in a living organism. Compelling evidence supports a role for excess fatty acids synthesized in intramuscular space or dietary intermediates in the regulation of skeletal muscle function. Excess FFA and lipid dro...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-03, Vol.21 (6), p.1949
Main Authors: Park, Sung Sup, Seo, Young-Kyo
Format: Article
Language:English
Subjects:
Accumulation
Diabetes mellitus (non-insulin dependent)
free fatty acid
Glucose
Glucose transporter
Insulin
Insulin resistance
insulin sensitivity
Intermediates
Kinases
Lipids
Metabolic disorders
metabolic dysfunction
Molecular modelling
Muscles
Review
Skeletal muscle
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Summary:Both glucose and free fatty acids (FFAs) are used as fuel sources for energy production in a living organism. Compelling evidence supports a role for excess fatty acids synthesized in intramuscular space or dietary intermediates in the regulation of skeletal muscle function. Excess FFA and lipid droplets leads to intramuscular accumulation of lipid intermediates. The resulting downregulation of the insulin signaling cascade prevents the translocation of glucose transporter to the plasma membrane and glucose uptake into skeletal muscle, leading to metabolic disorders such as type 2 diabetes. The mechanisms underlining metabolic dysfunction in skeletal muscle include accumulation of intracellular lipid derivatives from elevated plasma FFAs. This paper provides a review of the molecular mechanisms underlying insulin-related signaling pathways after excess accumulation of lipids.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21061949