Retrospective analysis of different therapeutic approaches for retroperitoneal duodenal perforations

• Published in: Scientific reports 2022-06, Vol.12 (1), p.10243-10243, Article 10243
• Main Authors: Yurttas, Can, Thiel, Christian, Wichmann, Dörte, Horvath, Philipp, Strohäker, Jens, Bongers, Malte Niklas, Schenk, Martin, Stüker, Dietmar, Königsrainer, Alfred, Thiel, Karolin
• Format: Article
• Language: English
• Subjects: 692/308/409; 692/308/53/2422; Endoscopy; Humanities and Social Sciences; Morbidity; multidisciplinary; Parenteral nutrition; Patients; Pressure; Retroperitoneum; Science; Science (multidisciplinary); Surgery
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-14278-8

Surgical therapy of duodenal perforation into the retroperitoneum entails high morbidity. Conservative treatment and endoscopic negative pressure therapy have been suggested as promising therapeutic alternatives. We aimed to retrospectively assess outcomes of patients treated for duodenal perforation to the retroperitoneum at our department. A retrospective analysis of all patients that were treated for duodenal perforation to the retroperitoneum at our institution between 2010 and 2021 was conducted. Different therapeutic approaches with associated complications within 30 days, length of in-hospital stay, number of readmissions and necessity of parenteral nutrition were assessed. We included thirteen patients in our final analysis. Six patients underwent surgery, five patients were treated conservatively and two patients received interventional treatment by endoscopic negative pressure therapy. Length of stay was shorter in patients treated conservatively. One patient following conservative and surgical treatment each was readmitted to hospital within 30 days after initial therapy whereas no readmissions after interventional treatment occurred. There was no failure of therapy in patients treated without surgery whereas four (66.7%) of six patients required revision surgery following primary surgical therapy. Conservative and interventional treatment were associated with fewer complications than surgical therapy which involves high morbidity. Conservative and interventional treatment using endoscopic negative pressure therapy in selected patients might constitute appropriate therapeutic alternatives for duodenal perforations to the retroperitoneum.