Unveiling the Hidden Potential of Simple but Promising Blood Cell Parameters on Acute Myocardial Infarction Prognostication

Background: Non-ST-elevation myocardial infarction (NSTEMI), a disease of mounting interest, continues to pose challenges and cast shadows of doubt on determining the optimal timing for revascularization. The current guidelines on NSTEMI recommend coronary angiography based on the GRACE score, empha...

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Published in:Applied sciences 2024-03, Vol.14 (6), p.2545
Main Authors: Jercălău, Cosmina Elena, Andrei, Cătălina Liliana, Brezeanu, Lavinia Nicoleta, Darabont, Roxana Oana, Guberna, Suzana, Postolea, Gabriela, Ceban, Octavian, Sinescu, Crina Julieta
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Analysis
Angina pectoris
biomarkers
Blood
Blood platelets
Body mass index
coronary angiography
Creatinine
Diabetes
Disease
Ethnicity
Heart attack
Heart attacks
Hematology
Hospitals
Ischemia
Laboratories
Medical imaging
Medical prognosis
Medical research
Medicine, Experimental
Mortality
non-ST-elevation myocardial infarction
Patients
prognosis
Regression analysis
score risk
Statistical analysis
Citations: Items that this one cites
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Summary:Background: Non-ST-elevation myocardial infarction (NSTEMI), a disease of mounting interest, continues to pose challenges and cast shadows of doubt on determining the optimal timing for revascularization. The current guidelines on NSTEMI recommend coronary angiography based on the GRACE score, emphasizing the critical need for early invasive assessment (within 24 h); very-high-risk patients have to undergo this intervention even sooner, within 2 h. We believe that a reality check of these assumptions is needed and that we should endeavor to update these strategies using new predictive markers. Materials and methods: Our study included patients hospitalized for NSTEMI over the course of 16 months. Simple blood parameters, namely MCV (mean corpuscular volume), MPV (mean platelet volume), RDW (red blood cell distribution width), and PDW (platelet distribution width), were analyzed in correlation with the extent of the myocardial infarction area and with complications during hospitalization and at 30-day follow-up. Results: The parameters mentioned above have been identified as statistically relevant indicators of prognosis in patients with NSTEMI. Conclusions: In the present day, living in the world of the blue sky concept allows us to search for new diagnostic algorithms. Therefore, the combination of these parameters can constitute the DNA strands of a new and up-to-date score stratification.
ISSN:2076-3417
2076-3417
DOI:10.3390/app14062545