X-ray Induced Hydroxyl Radical Generation by GdYVO4:Eu3+ Nanoparticles in Aqueous Solution: Main Mechanisms

We report on strong X-ray-induced hydroxyl radical (. O H ) generation in an aqueous solution containing UV light pre-treated GdYVO4:Eu3+ nanoparticles (L-GdYVO). The methods of optical spectroscopy were used to detect . O H in the solutions. The complex nature of the mechanism of . O H generation h...

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Published in:Crystals (Basel) 2020-05, Vol.10 (5), p.370
Main Authors: Maksimchuk, Pavel, Yefimova, Svetlana, Omielaieva, Valeriia, Hubenko, Kateryna, Klochkov, Vladimir, Opolonin, Oleksandr, Malyukin, Yuri
Format: Article
Language:English
Subjects:
Aqueous solutions
Cancer therapies
Efficiency
Energy
Europium
hydroxyl radical generation
Hydroxyl radicals
Hypoxia
Microscopy
nanocrystals
Nanomaterials
Nanoparticles
Pretreatment
Radiation therapy
Radiation tolerance
radioprotective effect
Skin cancer
Spectrum analysis
Tumors
Ultraviolet radiation
Valence band
X ray irradiation
X-rays
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cited_by cdi_FETCH-LOGICAL-c300t-624d84337007f7a2049680d4e3a31d6374422fac3e201e2829c4eafbbee967a93
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container_issue 5
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container_title Crystals (Basel)
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creator Maksimchuk, Pavel
Yefimova, Svetlana
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description We report on strong X-ray-induced hydroxyl radical (. O H ) generation in an aqueous solution containing UV light pre-treated GdYVO4:Eu3+ nanoparticles (L-GdYVO). The methods of optical spectroscopy were used to detect . O H in the solutions. The complex nature of the mechanism of . O H generation has been revealed and discussed. The experimental data obtained indicate that the mechanism of . O H generation is associated with two main processes: (i) direct . O H generation with the participation of thermalized h+ formed at X-ray irradiation, and (ii) X-ray-facilitated jumps of h+ formed in the nanoparticles’ (NPs’) valence band at UV light pre-treatment and trapped in local levels formed by random scattering potential. At the same time, for GdYVO4:Eu3+ nanoparticles, which were not exposed to UV light before the X-ray irradiation (D-GdYVO), a strong radioprotective effect ascribed to the electron-donation properties of V4+ ions was observed. Thus, depending on the pre-treatment condition, we can change the redox properties of GdYVO4:Eu3+ NPs in an opposite direction, which makes this nanomaterial a unique theranostic agent for radiation therapy (RT) enhancement, allowing the problem of radiation therapy (RT)-resistant hypoxic tumours to be overcome.
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O H ) generation in an aqueous solution containing UV light pre-treated GdYVO4:Eu3+ nanoparticles (L-GdYVO). The methods of optical spectroscopy were used to detect . O H in the solutions. The complex nature of the mechanism of . O H generation has been revealed and discussed. The experimental data obtained indicate that the mechanism of . O H generation is associated with two main processes: (i) direct . O H generation with the participation of thermalized h+ formed at X-ray irradiation, and (ii) X-ray-facilitated jumps of h+ formed in the nanoparticles’ (NPs’) valence band at UV light pre-treatment and trapped in local levels formed by random scattering potential. At the same time, for GdYVO4:Eu3+ nanoparticles, which were not exposed to UV light before the X-ray irradiation (D-GdYVO), a strong radioprotective effect ascribed to the electron-donation properties of V4+ ions was observed. 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subjects Aqueous solutions
Cancer therapies
Efficiency
Energy
Europium
hydroxyl radical generation
Hydroxyl radicals
Hypoxia
Microscopy
nanocrystals
Nanomaterials
Nanoparticles
Pretreatment
Radiation therapy
Radiation tolerance
radioprotective effect
Skin cancer
Spectrum analysis
Tumors
Ultraviolet radiation
Valence band
X ray irradiation
X-rays
title X-ray Induced Hydroxyl Radical Generation by GdYVO4:Eu3+ Nanoparticles in Aqueous Solution: Main Mechanisms
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