Ionic liquid-assisted cellulose coating of chitosan hydrogel beads and their application as drug carriers

The present study proposes a simple yet effective method of cellulose coating onto chitosan (CS) hydrogel beads and application thereof as drug carriers. The beads were coated with cellulose dissolved in 1-ethyl-3-methylimidazolium acetate, an ionic liquid (IL) via a one-pot one-step process. Water...

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Bibliographic Details
Published in:Scientific reports 2020-08, Vol.10 (1), p.13905-8, Article 13905
Main Authors: Song, Myung-Hee, Pham, Thi Phuong Thuy, Yun, Yeoung-Sang
Format: Article
Language:English
Subjects:
639/301/923/1027
639/638/224/907
Acetic acid
Cellulose
Cellulose - chemistry
Cellulose - ultrastructure
Chitosan
Chitosan - chemistry
Coatings
Drug Carriers - chemistry
Drug delivery
Drug Liberation
Humanities and Social Sciences
Hydrogels
Hydrogels - chemistry
Ionic Liquids - chemistry
Ions
Microspheres
multidisciplinary
Science
Science (multidisciplinary)
Spectroscopy, Fourier Transform Infrared
Verapamil
Verapamil - pharmacology
X-Ray Diffraction
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Summary:The present study proposes a simple yet effective method of cellulose coating onto chitosan (CS) hydrogel beads and application thereof as drug carriers. The beads were coated with cellulose dissolved in 1-ethyl-3-methylimidazolium acetate, an ionic liquid (IL) via a one-pot one-step process. Water molecules present in the CS beads diffused outward upon contact with the cellulose–IL mixture and acted as an anti-solvent. This allowed the surface of the beads to be coated with the regenerated cellulose. The regenerated cellulose was characterized by FE-SEM, FT-IR, and XRD analyses. To test potential application of the cellulose-coated CS hydrogel beads as a drug carrier, verapamil hydrochloride (VRP), used as a model drug, was impregnated into the beads. When the VRP-impregnated beads were immersed in the simulated gastric fluid (pH 1.2), the VRP was released in an almost ideal linear pattern. This easily fabricated cellulose-coated CS beads showed the possibility for application as carriers for drug release control.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-70900-7