Kisspeptin and Testicular Function-Is it Necessary?

The role of kisspeptin in stimulating hypothalamic GnRH is undisputed. However, the role of kisspeptin signaling in testicular function is less clear. The testes are essential for male reproduction through their functions of spermatogenesis and steroidogenesis. Our review focused on the current lite...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-04, Vol.21 (8), p.2958
Main Authors: Sharma, Aditi, Thaventhiran, Thilipan, Minhas, Suks, Dhillo, Waljit S, Jayasena, Channa N
Format: Article
Language:English
Subjects:
Animals
Current distribution
Gene expression
Gene Expression Regulation
Gonadotropin-releasing hormone
Hormones
Humans
Hypothalamus
Kiss1 protein
kisspeptin
kisspeptin receptor
Kisspeptins - genetics
Kisspeptins - metabolism
Kisspeptins - pharmacology
Leydig cells
Male
Mammals
Monkeys & apes
Mutation
Neuropeptides
Paracrine signalling
Peptides
Physiological effects
Physiology
Puberty
Review
Sertoli cells
Signal Transduction
Sperm
Spermatogenesis
Spermatogenesis - genetics
spermatozoa
Steroidogenesis
Steroids - biosynthesis
Studies
Testes
Testis - metabolism
Testosterone
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Summary:The role of kisspeptin in stimulating hypothalamic GnRH is undisputed. However, the role of kisspeptin signaling in testicular function is less clear. The testes are essential for male reproduction through their functions of spermatogenesis and steroidogenesis. Our review focused on the current literature investigating the distribution, regulation and effects of kisspeptin and its receptor (KISS1/KISS1R) within the testes of species studied to date. There is substantial evidence of localised KISS1/KISS1R expression and peptide distribution in the testes. However, variability is observed in the testicular cell types expressing KISS1/KISS1R. Evidence is presented for modulation of steroidogenesis and sperm function by kisspeptin signaling. However, the physiological importance of such effects, and whether these are paracrine or endocrine manifestations, remain unclear.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21082958