Gastritis Cystica Profunda: A Rare Disease, a Challenging Diagnosis, and an Uncertain Malignant Potential: A Case Report and Review of the Literature

Gastritis cystica profunda (GCP) has been defined as a rare submucosal benign gastric lesion with cystic gland growth. Due to its unclear etiopathogenesis, this lesion is often misdiagnosed and mistaken for other gastric masses. Currently, a standardized treatment for GCP lesions is still missing. H...

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Bibliographic Details
Published in:Medicina (Kaunas, Lithuania) Lithuania), 2023-10, Vol.59 (10), p.1770
Main Authors: De Stefano, Francesca, Graziano, Giorgio M. P, Viganò, Jacopo, Mauro, Aurelio, Peloso, Andrea, Peverada, Jacopo, Fellegara, Raffaele, Vanoli, Alessandro, Faillace, Giuseppe G, Ansaloni, Luca
Format: Article
Language:English
Subjects:
Abdomen
Anticoagulants
Biopsy
Case Report
Case reports
Cysts
Diagnosis
ectopic gastric glands
endoscopic ultrasound
Endoscopy
Etiology
gastric submucosal lesion
gastric surgery
Gastritis
gastritis cystica profunda
Hemoglobin
Hyperplasia
Inflammation
Ischemia
Patients
Peptic ulcer
Stomach
Surgery
Sutures
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Summary:Gastritis cystica profunda (GCP) has been defined as a rare submucosal benign gastric lesion with cystic gland growth. Due to its unclear etiopathogenesis, this lesion is often misdiagnosed and mistaken for other gastric masses. Currently, a standardized treatment for GCP lesions is still missing. Here, we illustrate a case of a patient admitted to our general surgery department for melena and general discomfort. No history of peptic ulcer or gastric surgery was present. Upper GI endoscopy was performed, showing a distal gastric lesion with a small ulceration on the top. CT-scan and endoscopic ultrasound confirmed the presence of the lesion, compatible with a gastric stromal tumor, without showing any eventual metastasis. Surgical gastric resection was performed. Histological findings were diagnostic for GCP, with cistically ectasic submucosal glands, chronic inflammation, eosinophilic infiltration and foveal hyperplasia. GCP is a very exceptional cause of upper-GI bleeding with specific histological features. Its diagnosis as well as its therapy are challenging, resulting in several pitfalls. Even though it is a rare entity, GCP should always be considered in the differential diagnosis of gastric submucosal lesions.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina59101770