Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview

Reconstruction of long-bone segmental defects (LBSDs) has been one of the biggest challenges in orthopaedics. Biomaterials for the reconstruction are required to be strong, osteoinductive, osteoconductive, and allowing for fast angiogenesis, without causing any immune rejection or disease transmissi...

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Bibliographic Details
Published in:Journal of orthopaedic translation 2020-05, Vol.22, p.26-33
Main Authors: Zhang, Meng, Matinlinna, Jukka P., Tsoi, James K.H., Liu, Wenlong, Cui, Xu, Lu, William W., Pan, Haobo
Format: Article
Language:English
Subjects:
Allograft
Artificial material
Autograft
Biomaterial
Long-bone segmental defect reconstruction
Review
Tissue engineering
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Summary:Reconstruction of long-bone segmental defects (LBSDs) has been one of the biggest challenges in orthopaedics. Biomaterials for the reconstruction are required to be strong, osteoinductive, osteoconductive, and allowing for fast angiogenesis, without causing any immune rejection or disease transmission. There are four main types of biomaterials including autograft, allograft, artificial material, and tissue-engineered bone. Remarkable progress has been made in LBSD reconstruction biomaterials in the last ten years. Our aim is to summarize recent developments in the divided four biomaterials utilized in the LBSD reconstruction to provide the clinicians with new information and comprehension from the biomaterial point of view.
ISSN:2214-031X
2214-0328
DOI:10.1016/j.jot.2019.09.005