Proteotoxicity and Neurodegenerative Diseases

Neurodegenerative diseases are a major burden for our society, affecting millions of people worldwide. A main goal of past and current research is to enhance our understanding of the mechanisms underlying proteotoxicity, a common theme among these incurable and debilitating conditions. Cell proteome...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-08, Vol.21 (16), p.5646
Main Authors: Ruz, Clara, Alcantud, Jose Luis, Vives Montero, Francisco, Duran, Raquel, Bandres-Ciga, Sara
Format: Article
Language:English
Subjects:
Aging
Alzheimer's disease
Amyotrophic Lateral Sclerosis
Animals
Apoptosis
Autophagy
Cell division
Deoxyribonucleic acid
Disease
DNA
Etiology
Humans
Huntington disease
Huntingtons disease
Kinases
Nervous system
Neurodegeneration
Neurodegenerative Diseases - drug therapy
Neurodegenerative Diseases - pathology
Parkinson's disease
Protein Aggregates
Proteins
Proteins - toxicity
Proteomes
proteotoxicity
Review
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Summary:Neurodegenerative diseases are a major burden for our society, affecting millions of people worldwide. A main goal of past and current research is to enhance our understanding of the mechanisms underlying proteotoxicity, a common theme among these incurable and debilitating conditions. Cell proteome alteration is considered to be one of the main driving forces that triggers neurodegeneration, and unraveling the biological complexity behind the affected molecular pathways constitutes a daunting challenge. This review summarizes the current state on key processes that lead to cellular proteotoxicity in Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, providing a comprehensive landscape of recent literature. A foundational understanding of how proteotoxicity affects disease etiology and progression may provide essential insight towards potential targets amenable of therapeutic intervention.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21165646