Impaired cardiac pumping function and increased afterload as determinants of early hemodynamic alterations in Cushing disease

The long-term hypercortisolemia of Cushing disease (CD) may lead to hemodynamic disorders by increasing subclinical cardiac and vascular dysfunction. The purpose of this observational cohort study was to assess the relationship between hemodynamic parameters evaluated via impedance cardiography (ICG...

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Published in:Scientific reports 2025-01, Vol.15 (1), p.233-12, Article 233
Main Authors: Włochacz, Agnieszka, Krzesiński, Paweł, Uziębło-Życzkowska, Beata, Witek, Przemysław, Zieliński, Grzegorz, Kazimierczak, Anna, Wierzbowski, Robert, Banak, Małgorzata, Gielerak, Grzegorz
Format: Article
Language:English
Subjects:
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Adrenocorticotropic hormone
Adult
Cardiography, Impedance
Cohort Studies
Coronary artery disease
Cushing disease
Cushing syndrome
Cushing's disease
Echocardiography
Female
Global longitudinal strain
Heart diseases
Hemodynamic disorders
Hemodynamics
Humanities and Social Sciences
Humans
Impedance cardiography
Male
Middle Aged
multidisciplinary
Nervous system diseases
Observational studies
Pituitary
Pituitary ACTH Hypersecretion - complications
Pituitary ACTH Hypersecretion - physiopathology
Pituitary neuroendocrine tumor
Science
Science (multidisciplinary)
Stroke Volume
Vascular Resistance
Ventricle
Ventricular Function, Left - physiology
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Summary:The long-term hypercortisolemia of Cushing disease (CD) may lead to hemodynamic disorders by increasing subclinical cardiac and vascular dysfunction. The purpose of this observational cohort study was to assess the relationship between hemodynamic parameters evaluated via impedance cardiography (ICG) and echocardiographic parameters reflecting left ventricular function in 54 patients newly diagnosed with CD. The parameters assessed via ICG included stroke volume index (SI), cardiac index (CI), acceleration index (ACI), velocity index (VI), systemic vascular resistance index (SVRI), total artery compliance index (TACI). The echocardiographic parameters included left ventricular mass index (LVMI) and left ventricular systolic and diastolic parameters. Higher LVMI values were associated with lower SI (p = 0.003), CI (p = 0.001), VI (p = 0.048), TACI (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-84888-x