Loading…
Molecular coordination of Staphylococcus aureus cell division
The bacterial cell wall is essential for viability, but despite its ability to withstand internal turgor must remain dynamic to permit growth and division. Peptidoglycan is the major cell wall structural polymer, whose synthesis requires multiple interacting components. The human pathogen is a prola...
Saved in:
| Published in: | eLife 2018-02, Vol.7 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c475t-2a1453c096061f68bf1aa1de9cb28d4c203aa21e00625a0e2e02ee3cb0ed21473 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c475t-2a1453c096061f68bf1aa1de9cb28d4c203aa21e00625a0e2e02ee3cb0ed21473 |
| container_end_page | |
| container_issue | |
| container_start_page | |
| container_title | eLife |
| container_volume | 7 |
| creator | Lund, Victoria A Wacnik, Katarzyna Turner, Robert D Cotterell, Bryony E Walther, Christa G Fenn, Samuel J Grein, Fabian Wollman, Adam Jm Leake, Mark C Olivier, Nicolas Cadby, Ashley Mesnage, Stéphane Jones, Simon Foster, Simon J |
| description | The bacterial cell wall is essential for viability, but despite its ability to withstand internal turgor must remain dynamic to permit growth and division. Peptidoglycan is the major cell wall structural polymer, whose synthesis requires multiple interacting components. The human pathogen
is a prolate spheroid that divides in three orthogonal planes. Here, we have integrated cellular morphology during division with molecular level resolution imaging of peptidoglycan synthesis and the components responsible. Synthesis occurs across the developing septal surface in a diffuse pattern, a necessity of the observed septal geometry, that is matched by variegated division component distribution. Synthesis continues after septal annulus completion, where the core division component FtsZ remains. The novel molecular level information requires re-evaluation of the growth and division processes leading to a new conceptual model, whereby the cell cycle is expedited by a set of functionally connected but not regularly distributed components. |
| doi_str_mv | 10.7554/eLife.32057 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_e7bf4c1659a047a0972561a7ebc7c0c9</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_e7bf4c1659a047a0972561a7ebc7c0c9</doaj_id><sourcerecordid>2007114377</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-2a1453c096061f68bf1aa1de9cb28d4c203aa21e00625a0e2e02ee3cb0ed21473</originalsourceid><addsrcrecordid>eNpdkc9rFDEcxQdRbKk9eZcBL4Jsm9-ZHBSkqC1s6UEFb-E73_lOm2V2siYzhf73Znfb0jaXF5IPj8d7VfWesxOrtTqlZejpRAqm7avqsAhbsEb9ff3kflAd57xi5VjVNNy9rQ6EU0ZLZw-rL5dxIJwHSDXGmLowwhTiWMe-_jXB5uZuiBgR51zDnKgI0jDUXbgNuWDvqjc9DJmO7_Wo-vPj---z88Xy6ufF2bflApXV00IAV1oic4YZ3pum7TkA78hhK5pOoWASQHBizAgNjAQxQSSxZdQJrqw8qi72vl2Eld-ksIZ05yMEv3uI6dpDmgIO5Mm2vUJutAOmLDBnhTYcLLVokaErXl_3Xpu5XVOHNE4Jhmemz3_GcOOv463XTclieDH4dG-Q4r-Z8uTXIW9rgZHinL0oRXOupN3m_vgCXcU5jaWqLeW4UU6yQn3eU5hizon6xzCc-e3Kfrey361c6A9P8z-yD5vK_yCvow8</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2009164930</pqid></control><display><type>article</type><title>Molecular coordination of Staphylococcus aureus cell division</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Lund, Victoria A ; Wacnik, Katarzyna ; Turner, Robert D ; Cotterell, Bryony E ; Walther, Christa G ; Fenn, Samuel J ; Grein, Fabian ; Wollman, Adam Jm ; Leake, Mark C ; Olivier, Nicolas ; Cadby, Ashley ; Mesnage, Stéphane ; Jones, Simon ; Foster, Simon J</creator><creatorcontrib>Lund, Victoria A ; Wacnik, Katarzyna ; Turner, Robert D ; Cotterell, Bryony E ; Walther, Christa G ; Fenn, Samuel J ; Grein, Fabian ; Wollman, Adam Jm ; Leake, Mark C ; Olivier, Nicolas ; Cadby, Ashley ; Mesnage, Stéphane ; Jones, Simon ; Foster, Simon J</creatorcontrib><description>The bacterial cell wall is essential for viability, but despite its ability to withstand internal turgor must remain dynamic to permit growth and division. Peptidoglycan is the major cell wall structural polymer, whose synthesis requires multiple interacting components. The human pathogen
is a prolate spheroid that divides in three orthogonal planes. Here, we have integrated cellular morphology during division with molecular level resolution imaging of peptidoglycan synthesis and the components responsible. Synthesis occurs across the developing septal surface in a diffuse pattern, a necessity of the observed septal geometry, that is matched by variegated division component distribution. Synthesis continues after septal annulus completion, where the core division component FtsZ remains. The novel molecular level information requires re-evaluation of the growth and division processes leading to a new conceptual model, whereby the cell cycle is expedited by a set of functionally connected but not regularly distributed components.</description><identifier>ISSN: 2050-084X</identifier><identifier>EISSN: 2050-084X</identifier><identifier>DOI: 10.7554/eLife.32057</identifier><identifier>PMID: 29465397</identifier><language>eng</language><publisher>England: eLife Sciences Publications Ltd</publisher><subject>Bacteria ; Cell cycle ; Cell Division ; Cell wall ; Cell Wall - metabolism ; Cell walls ; Division ; Divisome ; Gene Expression Regulation, Bacterial ; Gene Regulatory Networks ; Localization ; Microbiology and Infectious Disease ; Microscopy ; Models, Biological ; Penicillin ; Peptidoglycan ; Peptidoglycan - metabolism ; Peptidoglycans ; Protein Interaction Maps ; Proteins ; Staphylococcus aureus ; Staphylococcus aureus - physiology ; Turgor</subject><ispartof>eLife, 2018-02, Vol.7</ispartof><rights>2018, Lund et al.</rights><rights>2018, Lund et al. This work is licensed under the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/3.0/ ) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018, Lund et al 2018 Lund et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-2a1453c096061f68bf1aa1de9cb28d4c203aa21e00625a0e2e02ee3cb0ed21473</citedby><cites>FETCH-LOGICAL-c475t-2a1453c096061f68bf1aa1de9cb28d4c203aa21e00625a0e2e02ee3cb0ed21473</cites><orcidid>0000-0002-5501-8131 ; 0000-0001-8043-7998 ; 0000-0002-9921-6746 ; 0000-0002-1637-2023 ; 0000-0002-8962-3102 ; 0000-0001-7432-7805 ; 0000-0002-1715-1249</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2009164930/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2009164930?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29465397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lund, Victoria A</creatorcontrib><creatorcontrib>Wacnik, Katarzyna</creatorcontrib><creatorcontrib>Turner, Robert D</creatorcontrib><creatorcontrib>Cotterell, Bryony E</creatorcontrib><creatorcontrib>Walther, Christa G</creatorcontrib><creatorcontrib>Fenn, Samuel J</creatorcontrib><creatorcontrib>Grein, Fabian</creatorcontrib><creatorcontrib>Wollman, Adam Jm</creatorcontrib><creatorcontrib>Leake, Mark C</creatorcontrib><creatorcontrib>Olivier, Nicolas</creatorcontrib><creatorcontrib>Cadby, Ashley</creatorcontrib><creatorcontrib>Mesnage, Stéphane</creatorcontrib><creatorcontrib>Jones, Simon</creatorcontrib><creatorcontrib>Foster, Simon J</creatorcontrib><title>Molecular coordination of Staphylococcus aureus cell division</title><title>eLife</title><addtitle>Elife</addtitle><description>The bacterial cell wall is essential for viability, but despite its ability to withstand internal turgor must remain dynamic to permit growth and division. Peptidoglycan is the major cell wall structural polymer, whose synthesis requires multiple interacting components. The human pathogen
is a prolate spheroid that divides in three orthogonal planes. Here, we have integrated cellular morphology during division with molecular level resolution imaging of peptidoglycan synthesis and the components responsible. Synthesis occurs across the developing septal surface in a diffuse pattern, a necessity of the observed septal geometry, that is matched by variegated division component distribution. Synthesis continues after septal annulus completion, where the core division component FtsZ remains. The novel molecular level information requires re-evaluation of the growth and division processes leading to a new conceptual model, whereby the cell cycle is expedited by a set of functionally connected but not regularly distributed components.</description><subject>Bacteria</subject><subject>Cell cycle</subject><subject>Cell Division</subject><subject>Cell wall</subject><subject>Cell Wall - metabolism</subject><subject>Cell walls</subject><subject>Division</subject><subject>Divisome</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Gene Regulatory Networks</subject><subject>Localization</subject><subject>Microbiology and Infectious Disease</subject><subject>Microscopy</subject><subject>Models, Biological</subject><subject>Penicillin</subject><subject>Peptidoglycan</subject><subject>Peptidoglycan - metabolism</subject><subject>Peptidoglycans</subject><subject>Protein Interaction Maps</subject><subject>Proteins</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - physiology</subject><subject>Turgor</subject><issn>2050-084X</issn><issn>2050-084X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkc9rFDEcxQdRbKk9eZcBL4Jsm9-ZHBSkqC1s6UEFb-E73_lOm2V2siYzhf73Znfb0jaXF5IPj8d7VfWesxOrtTqlZejpRAqm7avqsAhbsEb9ff3kflAd57xi5VjVNNy9rQ6EU0ZLZw-rL5dxIJwHSDXGmLowwhTiWMe-_jXB5uZuiBgR51zDnKgI0jDUXbgNuWDvqjc9DJmO7_Wo-vPj---z88Xy6ufF2bflApXV00IAV1oic4YZ3pum7TkA78hhK5pOoWASQHBizAgNjAQxQSSxZdQJrqw8qi72vl2Eld-ksIZ05yMEv3uI6dpDmgIO5Mm2vUJutAOmLDBnhTYcLLVokaErXl_3Xpu5XVOHNE4Jhmemz3_GcOOv463XTclieDH4dG-Q4r-Z8uTXIW9rgZHinL0oRXOupN3m_vgCXcU5jaWqLeW4UU6yQn3eU5hizon6xzCc-e3Kfrey361c6A9P8z-yD5vK_yCvow8</recordid><startdate>20180221</startdate><enddate>20180221</enddate><creator>Lund, Victoria A</creator><creator>Wacnik, Katarzyna</creator><creator>Turner, Robert D</creator><creator>Cotterell, Bryony E</creator><creator>Walther, Christa G</creator><creator>Fenn, Samuel J</creator><creator>Grein, Fabian</creator><creator>Wollman, Adam Jm</creator><creator>Leake, Mark C</creator><creator>Olivier, Nicolas</creator><creator>Cadby, Ashley</creator><creator>Mesnage, Stéphane</creator><creator>Jones, Simon</creator><creator>Foster, Simon J</creator><general>eLife Sciences Publications Ltd</general><general>eLife Sciences Publications, Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5501-8131</orcidid><orcidid>https://orcid.org/0000-0001-8043-7998</orcidid><orcidid>https://orcid.org/0000-0002-9921-6746</orcidid><orcidid>https://orcid.org/0000-0002-1637-2023</orcidid><orcidid>https://orcid.org/0000-0002-8962-3102</orcidid><orcidid>https://orcid.org/0000-0001-7432-7805</orcidid><orcidid>https://orcid.org/0000-0002-1715-1249</orcidid></search><sort><creationdate>20180221</creationdate><title>Molecular coordination of Staphylococcus aureus cell division</title><author>Lund, Victoria A ; Wacnik, Katarzyna ; Turner, Robert D ; Cotterell, Bryony E ; Walther, Christa G ; Fenn, Samuel J ; Grein, Fabian ; Wollman, Adam Jm ; Leake, Mark C ; Olivier, Nicolas ; Cadby, Ashley ; Mesnage, Stéphane ; Jones, Simon ; Foster, Simon J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-2a1453c096061f68bf1aa1de9cb28d4c203aa21e00625a0e2e02ee3cb0ed21473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Bacteria</topic><topic>Cell cycle</topic><topic>Cell Division</topic><topic>Cell wall</topic><topic>Cell Wall - metabolism</topic><topic>Cell walls</topic><topic>Division</topic><topic>Divisome</topic><topic>Gene Expression Regulation, Bacterial</topic><topic>Gene Regulatory Networks</topic><topic>Localization</topic><topic>Microbiology and Infectious Disease</topic><topic>Microscopy</topic><topic>Models, Biological</topic><topic>Penicillin</topic><topic>Peptidoglycan</topic><topic>Peptidoglycan - metabolism</topic><topic>Peptidoglycans</topic><topic>Protein Interaction Maps</topic><topic>Proteins</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - physiology</topic><topic>Turgor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lund, Victoria A</creatorcontrib><creatorcontrib>Wacnik, Katarzyna</creatorcontrib><creatorcontrib>Turner, Robert D</creatorcontrib><creatorcontrib>Cotterell, Bryony E</creatorcontrib><creatorcontrib>Walther, Christa G</creatorcontrib><creatorcontrib>Fenn, Samuel J</creatorcontrib><creatorcontrib>Grein, Fabian</creatorcontrib><creatorcontrib>Wollman, Adam Jm</creatorcontrib><creatorcontrib>Leake, Mark C</creatorcontrib><creatorcontrib>Olivier, Nicolas</creatorcontrib><creatorcontrib>Cadby, Ashley</creatorcontrib><creatorcontrib>Mesnage, Stéphane</creatorcontrib><creatorcontrib>Jones, Simon</creatorcontrib><creatorcontrib>Foster, Simon J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>eLife</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lund, Victoria A</au><au>Wacnik, Katarzyna</au><au>Turner, Robert D</au><au>Cotterell, Bryony E</au><au>Walther, Christa G</au><au>Fenn, Samuel J</au><au>Grein, Fabian</au><au>Wollman, Adam Jm</au><au>Leake, Mark C</au><au>Olivier, Nicolas</au><au>Cadby, Ashley</au><au>Mesnage, Stéphane</au><au>Jones, Simon</au><au>Foster, Simon J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular coordination of Staphylococcus aureus cell division</atitle><jtitle>eLife</jtitle><addtitle>Elife</addtitle><date>2018-02-21</date><risdate>2018</risdate><volume>7</volume><issn>2050-084X</issn><eissn>2050-084X</eissn><abstract>The bacterial cell wall is essential for viability, but despite its ability to withstand internal turgor must remain dynamic to permit growth and division. Peptidoglycan is the major cell wall structural polymer, whose synthesis requires multiple interacting components. The human pathogen
is a prolate spheroid that divides in three orthogonal planes. Here, we have integrated cellular morphology during division with molecular level resolution imaging of peptidoglycan synthesis and the components responsible. Synthesis occurs across the developing septal surface in a diffuse pattern, a necessity of the observed septal geometry, that is matched by variegated division component distribution. Synthesis continues after septal annulus completion, where the core division component FtsZ remains. The novel molecular level information requires re-evaluation of the growth and division processes leading to a new conceptual model, whereby the cell cycle is expedited by a set of functionally connected but not regularly distributed components.</abstract><cop>England</cop><pub>eLife Sciences Publications Ltd</pub><pmid>29465397</pmid><doi>10.7554/eLife.32057</doi><orcidid>https://orcid.org/0000-0002-5501-8131</orcidid><orcidid>https://orcid.org/0000-0001-8043-7998</orcidid><orcidid>https://orcid.org/0000-0002-9921-6746</orcidid><orcidid>https://orcid.org/0000-0002-1637-2023</orcidid><orcidid>https://orcid.org/0000-0002-8962-3102</orcidid><orcidid>https://orcid.org/0000-0001-7432-7805</orcidid><orcidid>https://orcid.org/0000-0002-1715-1249</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2050-084X |
| ispartof | eLife, 2018-02, Vol.7 |
| issn | 2050-084X 2050-084X |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_e7bf4c1659a047a0972561a7ebc7c0c9 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Bacteria Cell cycle Cell Division Cell wall Cell Wall - metabolism Cell walls Division Divisome Gene Expression Regulation, Bacterial Gene Regulatory Networks Localization Microbiology and Infectious Disease Microscopy Models, Biological Penicillin Peptidoglycan Peptidoglycan - metabolism Peptidoglycans Protein Interaction Maps Proteins Staphylococcus aureus Staphylococcus aureus - physiology Turgor |
| title | Molecular coordination of Staphylococcus aureus cell division |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T13%3A06%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Molecular%20coordination%20of%20Staphylococcus%20aureus%20cell%20division&rft.jtitle=eLife&rft.au=Lund,%20Victoria%20A&rft.date=2018-02-21&rft.volume=7&rft.issn=2050-084X&rft.eissn=2050-084X&rft_id=info:doi/10.7554/eLife.32057&rft_dat=%3Cproquest_doaj_%3E2007114377%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c475t-2a1453c096061f68bf1aa1de9cb28d4c203aa21e00625a0e2e02ee3cb0ed21473%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2009164930&rft_id=info:pmid/29465397&rfr_iscdi=true |