Preventive effect of pressed degreased walnut meal extracts on T2DM rats by regulating glucolipid metabolism and modulating gut bacteria flora

• Published in: Journal of functional foods 2020-01, Vol.64, p.103694, Article 103694
• Main Authors: Li, Yulan, Chen, Dan, Zhang, Feng, Lin, Yuping, Ma, Yage, Zhao, Shenglan, Chen, Chaoyin, Wang, Xiaoshuang, Liu, Ji
• Format: Article
• Language: English
• Subjects: Intestinal flora; Pressed degreased walnut meal extracts; Type 2 diabetes
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2019.103694

[Display omitted] •The degreased walnut meal extracts (WMP) significantly hindered hyperglycemic impacts of diabetogenic diet and drug STZ, held on glucose tolerance, and relieved insulin resistance in rat.•WMP prevented diabetogenic diet and drug STZ from damages of liver and islet of β cells in rats.•WMP impeded deleterious effects of diabetogenic diet and drug STZ on gut microbiota in rats. Pressed degreased walnut meal (WM) was prepared from walnut kernel by cold-press deoil. It was rich in polyphenols with high activities of lowering lipids, antioxidation, anti-inflammation, and others, but the hypoglycemic activity has scarcely been reported. The purpose of this research was to investigate the preventive effect of the extracts of WM (WMP) on T2DM rats and the regulation of WMP on intestinal flora. Some results showed that WMP significantly held FBG, FINS and GSP, OGTT, the serum and hepatic TG, TC, HDL-C, LDL-C, AST, ALT, LPS, TNF-α, IL-6, and the hepatic MDA, CAT, SOD, as well as, prevented the pathological damage of the liver and the pancreas. The results of 16SrDNA sequencing demonstrated that WMP impeded the changes of intestinal flora in feces, mainly including Firmicutes, Bacteroidetes, and Proteobacteria. These indicated that WMP had promising effects on T2DM, which could be associated with the modulation of gut bacteria.