Inflammatory Cytokines, Immune Cells, and Organ Interactions in Heart Failure

Despite mounting evidence demonstrating the significance of inflammation in the pathophysiological mechanisms of heart failure (HF), most large clinical trials that target the inflammatory responses in HF yielded neutral or even worsening outcomes. Further in-depth understanding about the roles of i...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in physiology 2021-07, Vol.12, p.695047
Main Authors: Li, Huihui, Chen, Chen, Wang, Dao Wen
Format: Article
Language:English
Subjects:
cytokine
heart failure
immune cells
inflammation
organs
Physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite mounting evidence demonstrating the significance of inflammation in the pathophysiological mechanisms of heart failure (HF), most large clinical trials that target the inflammatory responses in HF yielded neutral or even worsening outcomes. Further in-depth understanding about the roles of inflammation in the pathogenesis of HF is eagerly needed. This review summarizes cytokines, cardiac infiltrating immune cells, and extracardiac organs that orchestrate the complex inflammatory responses in HF and highlights emerging therapeutic targets.
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2021.695047