Novel Harziane Diterpenes from Deep-Sea Sediment Fungus Trichoderma sp. SCSIOW21 and Their Potential Anti-Inflammatory Effects

Five undescribed harziane-type diterpene derivatives, namely harzianol K ( ), harzianol L ( ), harzianol M ( ), harzianol N ( ), harzianol O ( ), along with two known compounds, hazianol J ( ) and harzianol A ( ) were isolated from the deep-sea sediment-derived fungus sp. SCSIOW21. The relative conf...

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Bibliographic Details
Published in:Marine drugs 2021-12, Vol.19 (12), p.689
Main Authors: Li, Hongxu, Liu, Xinyi, Li, Xiaofan, Hu, Zhangli, Wang, Liyan
Format: Article
Language:English
Subjects:
Analytical methods
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Aquatic Organisms
Carbon
Configurations
Crystallography
Cytotoxicity
Deep sea
Deep sea environments
Deep water
Diterpenes
Diterpenes - chemistry
Diterpenes - pharmacology
Fungi
harziane diterpenes
Inflammation
Magnetic resonance spectroscopy
Nitric Oxide - chemistry
NMR
NMR spectroscopy
NO inhibition
Nuclear magnetic resonance
Sediments
Spectrum analysis
Structure-Activity Relationship
Trichoderma
Trichoderma - chemistry
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Summary:Five undescribed harziane-type diterpene derivatives, namely harzianol K ( ), harzianol L ( ), harzianol M ( ), harzianol N ( ), harzianol O ( ), along with two known compounds, hazianol J ( ) and harzianol A ( ) were isolated from the deep-sea sediment-derived fungus sp. SCSIOW21. The relative configurations were determined by meticulous spectroscopic methods including 1D, 2D NMR spectroscopy, and HR-ESI-MS. The absolute configurations were established by the ECD curve calculations and the X-ray crystallographic analysis. These compounds ( , and - ) contributed to increasing the diversity of the caged harziane type diterpenes with highly congested skeleton characteristics. Harzianol J ( ) exhibited a weak anti-inflammatory effect with 81.8% NO inhibition at 100 µM.
ISSN:1660-3397
1660-3397
DOI:10.3390/md19120689