sFlt-1 and CA 15.3 are indicators of endothelial damage and pulmonary fibrosis in SARS-CoV-2 infection

COVID-19 pandemic led to a worldwide increase of hospitalizations for interstitial pneumonia with thrombosis complications, endothelial injury and multiorgan disease. Common CT findings include lung bilateral infiltrates, bilateral ground-glass opacities and/or consolidation whilst no current labora...

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Bibliographic Details
Published in:Scientific reports 2021-10, Vol.11 (1), p.19979-19979, Article 19979
Main Authors: Greco, Marilena, Suppressa, Salvatore, Lazzari, Roberta Assunta, Sicuro, Fernando, Catanese, Carmelo, Lobreglio, Giambattista
Format: Article
Language:English
Subjects:
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Coronaviruses
COVID-19
Disease
Fibrosis
Humanities and Social Sciences
Lung diseases
multidisciplinary
Pandemics
Patients
Pulmonary fibrosis
Science
Science (multidisciplinary)
Sepsis
Serum levels
Severe acute respiratory syndrome coronavirus 2
Thromboembolism
Thrombosis
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Summary:COVID-19 pandemic led to a worldwide increase of hospitalizations for interstitial pneumonia with thrombosis complications, endothelial injury and multiorgan disease. Common CT findings include lung bilateral infiltrates, bilateral ground-glass opacities and/or consolidation whilst no current laboratory parameter consents rapidly evaluation of COVID-19 risk and disease severity. In the present work we investigated the association of sFLT-1 and CA 15.3 with endothelial damage and pulmonary fibrosis. Serum sFlt-1 has been associated with endothelial injury and sepsis severity, CA 15.3 seems an alternative marker for KL-6 for fibrotic lung diseases and pulmonary interstitial damage. We analysed 262 SARS-CoV-2 patients with differing levels of clinical severity; we found an association of serum sFlt-1 (ROC AUC 0.902, decision threshold > 90.3 pg/mL, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-99470-y