Periodontal disease and cancer risk: A nationwide population-based cohort study

BackgroundAlthough emerging evidence suggests that periodontitis might increase the risk of cancer, comorbidity and lifestyle behaviors, such as smoking and body mass index (BMI), may have confounded this reported association. This study aimed to investigate whether chronic periodontitis is associat...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in oncology 2022-08, Vol.12, p.901098-901098
Main Authors: Kim, Eun Hwa, Nam, Sunghyun, Park, Chung Hyun, Kim, Yitak, Lee, Myeongjee, Ahn, Joong Bae, Shin, Sang Joon, Park, Yu Rang, Jung, Hoi In, Kim, Baek-Il, Jung, Inkyung, Kim, Han Sang
Format: Article
Language:English
Subjects:
cancer risk
cohort study
Oncology
oral inflammation
periodontal disease
periodontitis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BackgroundAlthough emerging evidence suggests that periodontitis might increase the risk of cancer, comorbidity and lifestyle behaviors, such as smoking and body mass index (BMI), may have confounded this reported association. This study aimed to investigate whether chronic periodontitis is associated with cancer risk using a large, nationwide database. MethodsWe conducted a population-based, retrospective cohort study using data from the Korean National Health Insurance Cohort Database obtained between January 2003 and December 2015. We included 713,201 individuals without a history of cancer who were followed up to 10 years. Confounding factors included demographic factors (age, sex, income, and residential area), lifestyle behaviors (smoking history and BMI), and comorbidities, such as hypertension, diabetes, heart failure, and pulmonary disease, using the Charlson Comorbidity Index. Multivariable Cox regression analysis was applied to estimate the adjusted hazard ratio (aHR) for cancer risk. ResultsOf the 713,201 participants, 53,075 had periodontitis and were placed in the periodontitis group; the remaining 660,126 individuals were included as the control group. Overall, the cumulative incidence of cancer in the periodontitis group was 2.2 times higher than that in the control group. The periodontitis group had an increased risk of total cancer compared to the control group after adjusting for age, sex, comorbidities, BMI, and smoking history (aHR, 1.129; 95% confidence interval [CI], 1.089-1.171; P
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.901098