MitopatHs: A new logically-framed tool for visualizing multiple mitochondrial pathways

• Published in: iScience 2021-04, Vol.24 (4), p.102324-102324, Article 102324
• Main Authors: Marchi, Saverio, Zanella, Marco, Pinton, Paolo, Crafa, Silvia, Boniolo, Giovanni
• Format: Article
• Language: English
• Subjects: Cell Biology; Molecular Network; Software
• ISSN: 2589-0042; 2589-0042
• DOI: 10.1016/j.isci.2021.102324

Mitochondria are key organelles inside the cell that house a wide range of molecular pathways involved in energy metabolism, ions homeostasis, and cell death. Several databases characterize the different mitochondrial aspects and thus support basic and clinical research. Here we present MitopatHs, a web-based data set that allows navigating among the biochemical signaling pathways (PatHs) of human (H) mitochondria (Mito). MitopatHs is designed to visualize and comprehend virtually all types of pathways in two complementary ways: a logical view, where the sequence of biochemical reactions is presented as logical deductions, and an intuitive graphical visualization, which enables the examination and the analysis of each step of the pathway. MitopatHs is a manually curated, open access and collaborative tool, whose goal is to enable the visualization and comprehension of complicated molecular routes in an easy and fast way. [Display omitted] •We present MitopatHs: a new tool for exploring mitochondrial pathways•A rigorous logical framework manages mitochondrial pathways as logical deductions•A graphical visualization allows us to conceptualize the entire process step-by-step•The MitopatHs' user can scrutinize a pathway by navigating through its reactions Cell Biology ; Molecular Network ; Software