Comparative analysis of African swine fever virus genotypes and serogroups

African swine fever virus (ASFV) causes highly lethal hemorrhagic disease among pigs, and ASFV's extreme antigenic diversity hinders vaccine development. We show that p72 ASFV phylogenetic analysis does not accurately define ASFV hemadsorption inhibition assay serogroups. Thus, conventional ASF...

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Bibliographic Details
Published in:Emerging infectious diseases 2015-02, Vol.21 (2), p.312-315
Main Authors: Malogolovkin, Alexander, Burmakina, Galina, Titov, Ilya, Sereda, Alexey, Gogin, Andrey, Baryshnikova, Elena, Kolbasov, Denis
Format: Article
Language:English
Subjects:
African Swine Fever - epidemiology
African Swine Fever - virology
African swine fever virus
African Swine Fever Virus - classification
African Swine Fever Virus - genetics
Animals
Comparative Analysis of African Swine Fever Virus Genotypes and Serogroups
Dispatch
Genes, Viral
Genetic aspects
Genotype
genotypes
Geography, Medical
Global Health
hemadsorption inhibition assay
Hog cholera
phylogenetic analysis
Phylogeny
Serogroup
serogroups
Swine
Vaccines
Virulence (Microbiology)
viruses
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Description
Summary:African swine fever virus (ASFV) causes highly lethal hemorrhagic disease among pigs, and ASFV's extreme antigenic diversity hinders vaccine development. We show that p72 ASFV phylogenetic analysis does not accurately define ASFV hemadsorption inhibition assay serogroups. Thus, conventional ASFV genotyping cannot discriminate between viruses of different virulence or predict efficacy of a specific ASFV vaccine.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2102.140649