Prediction of HF-Related Mortality Risk Using Genetic Risk Score Alone and in Combination With Traditional Risk Factors

Common variants may contribute to the variation of prognosis of heart failure (HF) among individual patients, but no systematical analysis was conducted using transcriptomic and whole exome sequencing (WES) data. We aimed to construct a genetic risk score (GRS) and estimate its potential as a predic...

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Bibliographic Details
Published in:Frontiers in cardiovascular medicine 2021-04, Vol.8, p.634966-634966
Main Authors: Hu, Dong, Xiao, Lei, Li, Shiyang, Hu, Senlin, Sun, Yang, Wang, Yan, Wang, Dao Wen
Format: Article
Language:English
Subjects:
Cardiovascular Medicine
genetic risk score
heart failure
prediction
prognosis
traditional risk factors
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Summary:Common variants may contribute to the variation of prognosis of heart failure (HF) among individual patients, but no systematical analysis was conducted using transcriptomic and whole exome sequencing (WES) data. We aimed to construct a genetic risk score (GRS) and estimate its potential as a predictive tool for HF-related mortality risk alone and in combination with traditional risk factors (TRFs). We reanalyzed the transcriptomic data of 177 failing hearts and 136 healthy donors. Differentially expressed genes (fold change >1.5 or
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2021.634966