Clinical characteristics and related risk factors of depression in patients with early COPD

• Published in: International journal of chronic obstructive pulmonary disease 2018-01, Vol.13, p.1583-1590
• Main Authors: Lee, Ji-Hoon, Park, Min A, Park, Myung Jae, Jo, Yong Suk
• Format: Article
• Language: English
• Subjects: Aged; Body mass index; Chi-Square Distribution; Chronic obstructive pulmonary disease; Comorbidity; Databases, Factual; depression; Depression (Mood disorder); Depression - diagnosis; Depression - epidemiology; Depression - psychology; Diabetes; Diabetes Mellitus - epidemiology; Diabetes Mellitus - psychology; early COPD; Early Diagnosis; Education; Female; Forced Expiratory Volume; Health surveys; Humans; Hypertension; Income; Kidney diseases; Logistic Models; Lung - physiopathology; Male; Mental depression; Middle Aged; Multivariate Analysis; Nutrition; Nutrition Surveys; Odds Ratio; Original Research; Patients; Population; Predictive Value of Tests; Prevalence; Prognosis; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - epidemiology; Pulmonary Disease, Chronic Obstructive - physiopathology; Pulmonary Disease, Chronic Obstructive - psychology; Quality of Life; Questionnaires; Regression analysis; Republic of Korea - epidemiology; Risk Factors; Sex Factors; Single Person; Spirometry; Surveys; Surveys and Questionnaires; Tuberculosis
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/COPD.S157165

Although depression is considered one of the comorbidities of COPD, the clinical characteristics of depression in patients with early COPD remain unknown. We aimed to use national-level data to identify the clinical features and risk factors of depression in patients with early COPD. We examined 7,550 subjects who were registered in the Korean National Health and Nutrition Examination Survey database of 2014 because that was the only year in which the Patient Health Questionnaire-9 for depression status was administered. Spirometry was used to identify patients with COPD whose forced expiratory volume in 1 second was 50% or more, and these patients were included in the analysis. Of the 211 subjects with early COPD, 14.2% also had depression, whereas 85.8% did not. The patients with depression were predominantly living alone and had a greater prevalence of diabetes compared with the patients without depression. The overall quality of life of the subjects with depression was lower than that of those without depression, and only the quality of life index correlated significantly with depression severity. In the multivariate regression analysis, female sex (adjusted OR, 1.79; 95% CI, 1.38-2.31;