Phospholipase C isozymes as effectors of Ras superfamily GTPases

The physiological effects of many extracellular stimuli are initiated through receptor-promoted activation of phospholipase C and inositol lipid signaling pathways. The historical view that phospholipase C-promoted signaling primarily occurs through activation of heterotrimeric G proteins or tyrosin...

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Bibliographic Details
Published in:Journal of lipid research 2009-04, Vol.50 (Suppl), p.S243-S248
Main Authors: Harden, T. Kendall, Hicks, Stephanie N., Sondek, John
Format: Article
Language:English
Subjects:
Animals
Enzyme Activation
inositol lipid signaling
Isoenzymes - metabolism
Rac
rac GTP-Binding Proteins - metabolism
Rap
ras Proteins - classification
ras Proteins - metabolism
Rho
rho GTP-Binding Proteins - metabolism
Signaling
Type C Phospholipases - metabolism
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Summary:The physiological effects of many extracellular stimuli are initiated through receptor-promoted activation of phospholipase C and inositol lipid signaling pathways. The historical view that phospholipase C-promoted signaling primarily occurs through activation of heterotrimeric G proteins or tyrosine kinases has expanded in recent years with the realization that at least three different mammalian phospholipase C isozymes are directly activated by members of the Ras superfamily of GTPases. Thus, Ras, Rap, Rac, and Rho GTPases all specifically regulate certain phospholipase C isozymes, and insight into the physiological significance of these signaling responses is beginning to accrue. High resolution three-dimensional structures of phospholipase C isozymes also are beginning to shed light on their mechanism of activation.
ISSN:0022-2275
1539-7262
DOI:10.1194/jlr.R800045-JLR200