Association between gut microbiota and glioblastoma: a Mendelian randomization study

Glioblastoma (GBM) is the most prevalent malignant brain tumor, significantly impacting the physical and mental wellbeing of patients. Several studies have demonstrated a close association between gut microbiota and the development of GBM. In this investigation, Mendelian randomization (MR) was empl...

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Bibliographic Details
Published in:Frontiers in genetics 2024-01, Vol.14, p.1308263-1308263
Main Authors: Wang, Song, Yin, Fangxu, Guo, Zheng, Li, Rui, Sun, Wei, Wang, Yuchao, Geng, Yichen, Sun, Chao, Sun, Daqing
Format: Article
Language:English
Subjects:
causality
Genetics
glioblastoma
gut microbiota
gut-brain axis
Mendelian randomization
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Summary:Glioblastoma (GBM) is the most prevalent malignant brain tumor, significantly impacting the physical and mental wellbeing of patients. Several studies have demonstrated a close association between gut microbiota and the development of GBM. In this investigation, Mendelian randomization (MR) was employed to rigorously evaluate the potential causal relationship between gut microbiota and GBM. We utilized summary statistics derived from genome-wide association studies (GWAS) encompassing 211 gut microbiota and GBM. The causal association between gut microbiota and GBM was scrutinized using Inverse Variance Weighted (IVW), MR-Egger, and Weighted Median (WM) methods. Cochrane's Q statistic was employed to conduct a heterogeneity test. MR-Pleiotropic Residuals and Outliers (MR-PRESSO) were applied to identify and eliminate SNPs with horizontal pleiotropic outliers. Additionally, Reverse MR was employed to assess the causal relationship between GBM and pertinent gut microbiota. The MR study estimates suggest that the nine gut microbiota remain stable, considering heterogeneity and sensitivity methods. Among these, the and were associated with an increased risk of GBM, whereas , , , , , , and were associated with a reduced risk of GBM. Following Benjamini and Hochberg (BH) correction, (OR = 0.04, 95% CI: 0.01-0.19, FDR = 0.003) was identified as playing a protective role against GBM. This groundbreaking study is the first to demonstrate that is significantly associated with a reduced risk of GBM. The modulation of for the treatment of GBM holds considerable potential clinical significance.
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2023.1308263