A cross-sectional study on the impact of hemodialysis duration on retinal nerve fiber layer thinning in hemodialysis patients

This study aimed to investigate the relationship between hemodialysis duration (HDD) and retinal nerve fiber layer (RNFL) thickness. A total of 60 patients receiving maintenance hemodialysis and 67 healthy controls were analyzed. Spectral domain optical coherence tomography (SD-OCT) was employed to...

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Bibliographic Details
Published in:Scientific reports 2024-08, Vol.14 (1), p.17824-9, Article 17824
Main Authors: Hong, Yiyi, Lan, Lin, Hu, Xiangyu, Zuo, Yuan, Deng, Meiqiu, Ye, Kun, Xu, Fan, Chen, Changzheng, Li, Min
Format: Article
Language:English
Subjects:
692/4022/1585/104/1586
692/699/3161/3164
Adult
Aged
Cardiovascular disease
Case-Control Studies
Chronic kidney disease
Cross-Sectional Studies
Dialyzers
Female
Hemodialysis
Hemoglobin
Hospitals
Humanities and Social Sciences
Humans
Intraocular Pressure - physiology
Kidney diseases
Male
Metabolism
Middle Aged
multidisciplinary
Nerve Fibers - pathology
Nervous system
Ophthalmology
Optic nerve
Optical coherence tomography
Optics
Renal Dialysis
Retina
Retina - diagnostic imaging
Retina - pathology
Retinal Ganglion Cells - pathology
Retinal nerve fiber layer
Science
Science (multidisciplinary)
Thinning
Time Factors
Tomography
Tomography, Optical Coherence - methods
Visual acuity
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Summary:This study aimed to investigate the relationship between hemodialysis duration (HDD) and retinal nerve fiber layer (RNFL) thickness. A total of 60 patients receiving maintenance hemodialysis and 67 healthy controls were analyzed. Spectral domain optical coherence tomography (SD-OCT) was employed to measure annular RNFL thicknesses. The hemodialysis group exhibited reduced temporal and inferior RNFL thicknesses relative to the control group. In hemodialysis patients, the inferior RNFL thickness was negatively correlated with HDD and positively correlated with intraocular pressure (IOP). Moreover, IOP was positively correlated with HDD. Mediation analysis showed that the negative correlation between HDD and inferior RNFL thickness was mediated by IOP. In conclusion, hemodialysis leads to temporal and inferior RNFL thinning, and the thickness reduction is proportional to hemodialysis duration. However, such changes are not induced by an increase in IOP.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-68589-z