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A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery
Administration of drugs via the buccal route has attracted much attention in recent years. However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge. Here, we propose a mussel-inspired mucoadhesive film. Ex vivo models sho...
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Published in: | Nature communications 2021-03, Vol.12 (1), p.1689-17, Article 1689 |
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creator | Hu, Shanshan Pei, Xibo Duan, Lunliang Zhu, Zhou Liu, Yanhua Chen, Junyu Chen, Tao Ji, Ping Wan, Qianbing Wang, Jian |
description | Administration of drugs via the buccal route has attracted much attention in recent years. However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge. Here, we propose a mussel-inspired mucoadhesive film. Ex vivo models show that this film can achieve strong adhesion to wet buccal tissues (up to 38.72 ± 10.94 kPa). We also demonstrate that the adhesion mechanism of this film relies on both physical association and covalent bonding between the film and mucus. Additionally, the film with incorporated polydopamine nanoparticles shows superior advantages for transport across the mucosal barrier, with improved drug bioavailability (~3.5-fold greater than observed with oral delivery) and therapeutic efficacy in oral mucositis models (~6.0-fold improvement in wound closure at day 5 compared with that observed with no treatment). We anticipate that this platform might aid the development of tissue adhesives and inspire the design of nanoparticle-based buccal delivery systems.
Minimally invasive drug delivery is of wide interest and oral tissue is an attractive target for this. Here, the authors report on the creation of mussel-inspired films for retention on the wet oral tissue for the delivery of drugs by diffusion and transport though the mucosal tissue. |
doi_str_mv | 10.1038/s41467-021-21989-5 |
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Minimally invasive drug delivery is of wide interest and oral tissue is an attractive target for this. 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However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge. Here, we propose a mussel-inspired mucoadhesive film. Ex vivo models show that this film can achieve strong adhesion to wet buccal tissues (up to 38.72 ± 10.94 kPa). We also demonstrate that the adhesion mechanism of this film relies on both physical association and covalent bonding between the film and mucus. Additionally, the film with incorporated polydopamine nanoparticles shows superior advantages for transport across the mucosal barrier, with improved drug bioavailability (~3.5-fold greater than observed with oral delivery) and therapeutic efficacy in oral mucositis models (~6.0-fold improvement in wound closure at day 5 compared with that observed with no treatment). We anticipate that this platform might aid the development of tissue adhesives and inspire the design of nanoparticle-based buccal delivery systems.
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However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge. Here, we propose a mussel-inspired mucoadhesive film. Ex vivo models show that this film can achieve strong adhesion to wet buccal tissues (up to 38.72 ± 10.94 kPa). We also demonstrate that the adhesion mechanism of this film relies on both physical association and covalent bonding between the film and mucus. Additionally, the film with incorporated polydopamine nanoparticles shows superior advantages for transport across the mucosal barrier, with improved drug bioavailability (~3.5-fold greater than observed with oral delivery) and therapeutic efficacy in oral mucositis models (~6.0-fold improvement in wound closure at day 5 compared with that observed with no treatment). We anticipate that this platform might aid the development of tissue adhesives and inspire the design of nanoparticle-based buccal delivery systems.
Minimally invasive drug delivery is of wide interest and oral tissue is an attractive target for this. Here, the authors report on the creation of mussel-inspired films for retention on the wet oral tissue for the delivery of drugs by diffusion and transport though the mucosal tissue.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33727548</pmid><doi>10.1038/s41467-021-21989-5</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-5137-0330</orcidid><orcidid>https://orcid.org/0000-0003-1717-5782</orcidid><orcidid>https://orcid.org/0000-0001-8233-1513</orcidid><orcidid>https://orcid.org/0000-0003-3324-483X</orcidid><orcidid>https://orcid.org/0000-0002-0028-5881</orcidid><orcidid>https://orcid.org/0000-0002-9643-9514</orcidid><orcidid>https://orcid.org/0000-0003-4277-1623</orcidid><orcidid>https://orcid.org/0000-0002-2608-1035</orcidid><orcidid>https://orcid.org/0000-0002-5658-5525</orcidid><oa>free_for_read</oa></addata></record> |
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recordid | cdi_doaj_primary_oai_doaj_org_article_e8948ace98584c409a9ddd62e3337eb5 |
source | PubMed (Medline); Nature; Publicly Available Content (ProQuest); Springer Nature - nature.com Journals - Fully Open Access |
subjects | 13/1 13/51 14/19 14/34 14/63 140/131 147/135 147/143 147/3 631/61/54/989 631/61/54/990 639/925/352/152 64/86 82/16 Adhesion Adhesive strength Adhesiveness Administration, Buccal Animals Bioavailability Biomimetics Bivalvia - chemistry Cell Line Dexamethasone - pharmacology Dihydroxyphenylalanine - chemistry Drug delivery Drug Delivery Systems Drug development Drug Liberation Humanities and Social Sciences Humans Indoles - toxicity Male Mollusks Mouth Mucosa - physiology Mucins - chemistry Mucosa Mucositis Mucus Mucus - chemistry multidisciplinary Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Particle Size Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Polylactic Acid-Polyglycolic Acid Copolymer - toxicity Polymers - toxicity Polyvinyl Alcohol - chemistry Polyvinyl Alcohol - toxicity Rats Rats, Sprague-Dawley Science Science (multidisciplinary) Spectrophotometry, Ultraviolet Swine Tissue Distribution Tissues Wound healing |
title | A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T11%3A59%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20mussel-inspired%20film%20for%20adhesion%20to%20wet%20buccal%20tissue%20and%20efficient%20buccal%20drug%20delivery&rft.jtitle=Nature%20communications&rft.au=Hu,%20Shanshan&rft.date=2021-03-16&rft.volume=12&rft.issue=1&rft.spage=1689&rft.epage=17&rft.pages=1689-17&rft.artnum=1689&rft.issn=2041-1723&rft.eissn=2041-1723&rft_id=info:doi/10.1038/s41467-021-21989-5&rft_dat=%3Cproquest_doaj_%3E2501654315%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c568t-68d5c395b71eed51fe7594b5ef046d330e4b46ace6c585d9352e6e19c2acebcb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2501654315&rft_id=info:pmid/33727548&rfr_iscdi=true |