Efficacy of single dose dermatological 0.1% tacrolimus Ointment in the treatment of vernal keratoconjunctivitis

Objective: To assess the safety of dermatological 0.1% tacrolimus ointment when used topically and its efficacy in the treatment of vernal keratoconvinctivtis. Method: The quasi-experimental, multi-centre study was conducted at the Gujranwala Medical College/District Headquarters Teaching Hospital,...

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Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2022-09, Vol.72 (9), p.1694-1698
Main Authors: Sharjeel, Muhammad, Iqbal, Usama, Jabran, Aamna, Mehmood, Asif, Mohiuddin, Memona
Format: Article
Language:English
Subjects:
Dermatologic agents
Dermatology
Dosage and administration
Drug therapy
Formulae, receipts, prescriptions
Keratoconjunctivitis
Patient outcomes
Tacrolimus
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Summary:Objective: To assess the safety of dermatological 0.1% tacrolimus ointment when used topically and its efficacy in the treatment of vernal keratoconvinctivtis. Method: The quasi-experimental, multi-centre study was conducted at the Gujranwala Medical College/District Headquarters Teaching Hospital, Gujranwala, and the Gomal Medial College/Mufti Mehmood Teaching Hospital, Dera Ismail Khan, Pakistan, from July 2019 to March 2020, and comprised patients of severe vernal keratoconvinctivtis. Symptoms and clinical signs were graded on a pre-devised scale. Patients were given small amount of tacrolimus 0.1% ointment applied to the inferior conjunctival fornix before going to bed. The duration of treatment was 3 months and the patients were followed up for up to 6 months. Data was analysed using SPSS 20. Results: Of the 50 patients, 30(60%) were males and 20(40%) were females. The overall mean age was 10.64±3.199 years. Mean symptom score and clinical signs score gradually reduced on each follow-up (p
ISSN:0030-9982
DOI:10.47391/JPMA.3541