Fermented Rice Germ Extract Ameliorates Abnormal Glucose Metabolism via Antioxidant Activity in Type 2 Diabetes Mellitus Mice

Rice germ is an abundant source of ferulic acid, which is known for its anti-oxidant activity. This study aimed to evaluate the regulatory effects of fermented rice germ extracts on hepatic glucose metabolism in C57BL/KsJ-db/db mice. Rice germ was fermented with Lactobacillus plantarum and extracted...

Full description

Saved in:
Bibliographic Details
Published in:Applied sciences 2021-04, Vol.11 (7), p.3091
Main Authors: Hyun, Ye Ji, Kim, Ju Gyeong, Jung, Sung Keun, Kim, Ji Yeon
Format: Article
Language:English
Subjects:
Acids
Antioxidants
Cholesterol
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diet
Ethanol
Experiments
Fermentation
Fermented food
Ferulic acid
Food intake
Gene expression
Gluconeogenesis
Glucose
Glucose metabolism
Glucose tolerance
Glycolysis
hepatic glucose metabolism
Homeostasis
Hyperglycemia
Hypoglycemia
hypoglycemia effect
Insulin resistance
Lipid peroxidation
Lipids
Liver
Malondialdehyde
Metabolism
Oxidants
Oxidative stress
Oxidizing agents
Phosphatase
Plant extracts
Rice
rice germ
Superoxide dismutase
Triglycerides
type 2 diabetes mellitus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rice germ is an abundant source of ferulic acid, which is known for its anti-oxidant activity. This study aimed to evaluate the regulatory effects of fermented rice germ extracts on hepatic glucose metabolism in C57BL/KsJ-db/db mice. Rice germ was fermented with Lactobacillus plantarum and extracted with 30% ethanol (RG_30E) or 50% ethanol (RG_50E). Mice were fed modified AIN-93 diets containing fermented rice germ extracts and ferulic acid for 8 weeks. RG_50E significantly reduced food intake as well as liver weight and RG_30E and RG_50E improved glucose homeostasis, as indicated by fasting blood glucose levels and glucose tolerance. Hepatic triglyceride and total cholesterol levels were significantly decreased in db/db mice fed RG_30E and RG_50E. The antioxidant capacity of RG_30E and RG_50E was confirmed by a decrease in malondialdehyde levels and an increase in hepatic superoxide dismutase activity. The expression of genes related to glycolysis and gluconeogenesis was significantly regulated by RG_30E and RG_50E. These results suggest that fermented rice germ extracts have the potential to regulate hypoglycemia and hepatic glucose metabolism in type 2 diabetes db/db mice.
ISSN:2076-3417
2076-3417
DOI:10.3390/app11073091