Optimization of Carvacrol Nanoemulsion for the Incorporation in Pectin Membranes: Influence on Their Load Capacity, Microstructure and Antibacterial Properties

Interest in developing novel wound dressings with antibacterial properties elaborated from natural sources continues to grow. In this study, a Tween-80 (T80)-stabilized carvacrol (CAR) emulsion was incorporated into pectin (PEC) membranes at 0 (control), 0.25, 0.50, and 1.00% (v/v). Membranes were o...

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Bibliographic Details
Published in:Materials research (São Carlos, São Paulo, Brazil) São Paulo, Brazil), 2022-01, Vol.25, p.1
Main Authors: Beltrán, O., Luna, M., Valbuena-Gregorio, E., Valdez-Melchor, R. G., Burruel-Ibarra, S. E., Quihui-Cota, L., Ruiz-Cruz, S., Juárez, J., López-Mata, M. A.
Format: Article
Language:English
Subjects:
antibacterial
carvacrol
E coli
emulsion
ENGINEERING, CHEMICAL
Entrapment
Hydrogen bonds
Infrared analysis
Infrared spectra
MATERIALS SCIENCE, MULTIDISCIPLINARY
membrane
Membranes
METALLURGY & METALLURGICAL ENGINEERING
Micelles
Microstructural analysis
Microstructure
Nanoemulsions
Optimization
Pectin
Spectrum analysis
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Summary:Interest in developing novel wound dressings with antibacterial properties elaborated from natural sources continues to grow. In this study, a Tween-80 (T80)-stabilized carvacrol (CAR) emulsion was incorporated into pectin (PEC) membranes at 0 (control), 0.25, 0.50, and 1.00% (v/v). Membranes were obtained by the dry-casting method, characterized by scanning electron microscopy, infrared spectroscopy, and CAR retention (HPLC), and tested for antibacterial activity. The retention percentage of CAR in the membranes ranged from 9.1-13.9%. Infrared spectra analysis indicated changes in the hydrogen bonds of the membranes that suggest an interaction between the polymer matrix and the CAR:T80 emulsion. Microstructural analysis of the membranes showed the presence of hole-like features on the surface (≈ 4-6 µm diameter) that indicate entrapment of the micelles in the matrix (microcapsules). The PEC-CAR membranes exhibited antibacterial activity against Escherichia coli and Staphylococcus aureus, two pathogens commonly associated with wounds and intra-hospital infections.
ISSN:1516-1439
1980-5373
1980-5373
DOI:10.1590/1980-5373-mr-2021-0534