Prognostic value of post-treatment serum soluble interleukin-2 receptor in newly diagnosed diffuse large B-cell lymphoma patients who achieved complete metabolic response following R-CHOP therapy

Patients with DLBCL achieving complete metabolic response (CMR) after initial treatment with R-CHOP generally have a favourable prognosis; however, there are no established prognostic biomarkers for relapse in these patients. Soluble interleukin-2 receptor (sIL-2R) levels at diagnosis are prognostic...

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Published in:Scientific reports 2023-08, Vol.13 (1), p.13713-13713, Article 13713
Main Authors: Shirouchi, Yuko, Nishimura, Noriko, Mishima, Yuko, Ishihara, Yuko, Asai, Hiroaki, Tamba, Mikako, Hirano, Mitsuhito, Hirano, Kei, Teramoto, Yukako, Yoshida, Kikuaki, Takeuchi, Kengo, Terauchi, Takashi, Maruyama, Dai
Format: Article
Language:English
Subjects:
631/67/1990
631/67/1990/291
631/67/1990/291/1621
631/67/1990/291/1621/1915
B-cell lymphoma
Cytokines
Humanities and Social Sciences
Interleukin 2
Lymphocytes B
Lymphoma
Medical prognosis
Metabolic response
Metabolism
multidisciplinary
Science
Science (multidisciplinary)
Survival
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Summary:Patients with DLBCL achieving complete metabolic response (CMR) after initial treatment with R-CHOP generally have a favourable prognosis; however, there are no established prognostic biomarkers for relapse in these patients. Soluble interleukin-2 receptor (sIL-2R) levels at diagnosis are prognostic factors in patients with DLBCL. However, the significance of post-treatment sIL-2R levels is unclear. To determine the significance of post-treatment serum sIL-2R levels on subsequent relapse and survival, we retrospectively analysed 485 patients with newly diagnosed DLBCL who received R-CHOP treatment and achieved CMR. The cumulative incidence of relapse (CIR) was significantly higher in patients with elevated post-treatment sIL-2R levels than in those with normal sIL-2R levels (five-year CIR; 38.8% vs. 12.8%). The prognostic value remained significant in multivariable analysis (hazard ratio, 2.30; p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-40026-7