Factors associated with the decision to administer β-lactams via prolonged infusion in patients with sepsis: a prospective observational cohort study

•Prolonged infusion (PI) of β-lactam was associated with a lower mortality in sepsis.•PI was not commonly applied and was more often used in severely ill patients.•PI had a survival benefit independent of disease severity. β-lactams are the most widely used antibiotics in sepsis. We aimed to explore...

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Published in:International journal of infectious diseases 2022-11, Vol.124, p.113-117
Main Authors: Mao, Yang, Xu, Nana, Yan, Meichen, Pang, Mingmin, Zhang, Xinyue, Wang, Haigang, Du, Juan, Wu, Dawei, Wang, Hao
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Language:English
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Conventional bolus infusion
Prolonged infusion
Sepsis
β-lactams
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container_title International journal of infectious diseases
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creator Mao, Yang
Xu, Nana
Yan, Meichen
Pang, Mingmin
Zhang, Xinyue
Wang, Haigang
Du, Juan
Wu, Dawei
Wang, Hao
description •Prolonged infusion (PI) of β-lactam was associated with a lower mortality in sepsis.•PI was not commonly applied and was more often used in severely ill patients.•PI had a survival benefit independent of disease severity. β-lactams are the most widely used antibiotics in sepsis. We aimed to explore the factors that drive physicians to choose prolonged infusion (PI) of β-lactams in septic patients. This prospective observational national cohort study was conducted in 40 ICUs at the teaching hospitals of 31 provinces in China between August 20, 2021 and September 20, 2021. Of the 441 enrolled patients, 265 (60.09%) received PI therapy. Multivariate analysis showed that multidrug-resistant bacterial infection and septic shock were independent factors associated with PI. However, our data showed that the survival benefit of PI use was evident in subgroups with less severe sepsis, including those with lower Charlson comorbidity index values (
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We aimed to explore the factors that drive physicians to choose prolonged infusion (PI) of β-lactams in septic patients. This prospective observational national cohort study was conducted in 40 ICUs at the teaching hospitals of 31 provinces in China between August 20, 2021 and September 20, 2021. Of the 441 enrolled patients, 265 (60.09%) received PI therapy. Multivariate analysis showed that multidrug-resistant bacterial infection and septic shock were independent factors associated with PI. However, our data showed that the survival benefit of PI use was evident in subgroups with less severe sepsis, including those with lower Charlson comorbidity index values (&lt;2), those without septic shock, and those with lower acute physiology and chronic health evaluation II scores (&lt;15). Univariate and multivariate Cox regression indicated that PI was an independent protective factor of 28d mortality, even after adjusting the variables associated with disease severity. 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subjects Conventional bolus infusion
Prolonged infusion
Sepsis
β-lactams
title Factors associated with the decision to administer β-lactams via prolonged infusion in patients with sepsis: a prospective observational cohort study
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