Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence

Mesenchymal stem cell (MSC) transplantation has been widely used as a potential treatment for a variety of diseases. However, the contradiction between the low survival rate of transplanted cells and the beneficial therapeutic effects has affected its clinical use. Lysosomes as organelles at the cen...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2022-02, Vol.10, p.817877-817877
Main Authors: Zhang, Weijun, Bai, Jinwu, Hang, Kai, Xu, Jianxiang, Zhou, Chengwei, Li, Lijun, Wang, Zhongxiang, Wang, Yibo, Wang, Kanbin, Xue, Deting
Format: Article
Language:English
Subjects:
Cell and Developmental Biology
lysosomal acidification
mesenchymal stem cells
senescence
V-ATPase
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Summary:Mesenchymal stem cell (MSC) transplantation has been widely used as a potential treatment for a variety of diseases. However, the contradiction between the low survival rate of transplanted cells and the beneficial therapeutic effects has affected its clinical use. Lysosomes as organelles at the center of cellular recycling and metabolic signaling, play essential roles in MSC homeostasis. In the first part of this review, we summarize the role of lysosomal acidification dysfunction in MSC senescence. In the second part, we summarize some of the potential strategies targeting lysosomal proteins to enhance the therapeutic effect of MSCs.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.817877