Modifiable factors associated with Huntington's disease progression in presymptomatic participants

Objective Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms. Our aim here was to identify factors that can be modified to slow disease progression even before the first symptoms appear. Methods We included 2636 pres...

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Bibliographic Details
Published in:Annals of clinical and translational neurology 2024-07, Vol.11 (7), p.1930-1941
Main Authors: Gil‐Salcedo, Andres, Massart, Renaud, Langavant, Laurent Cleret, Bachoud‐Levi, Anne‐Catherine
Format: Article
Language:English
Subjects:
Adult
Age
Alcohol
Anxiety
Asymptomatic Diseases
Body Mass Index
Disease Progression
Education
Female
Health behavior
Humans
Huntington Disease - genetics
Huntington Disease - physiopathology
Huntingtons disease
Machine learning
Male
Marital status
Metabolism
Middle Aged
Mutation
Prodromal Symptoms
Prospective Studies
Sociodemographics
Variables
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Summary:Objective Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms. Our aim here was to identify factors that can be modified to slow disease progression even before the first symptoms appear. Methods We included 2636 presymptomatic individuals (comparison with family controls) drawn from the prospective observational cohort Enroll‐HD, with more than 35 CAG repeats and at least two assessments of disease progression measured with the composite Huntington's disease rating Scale (cUHDRS). The association between sociodemographic factors, health behaviors, health history, and cUHDRS trajectory was assessed with a mixed‐effects random forest using partial dependence plots and Shapley additive explanation method. Results Participants were followed by an average of 3.4 (SD = 1.97) years. We confirmed the negative impact of age and a high number of CAG repeats. We found that a high level of education, a body mass index (BMI) 23 kg/m2 thereafter, alcohol consumption of
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.52120