Extrachromosomal circular DNA: a new potential role in cancer progression

Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles), microDNA, and extrachromosomal DNA (ecDNA) ac...

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Bibliographic Details
Published in:Journal of translational medicine 2021-06, Vol.19 (1), p.1-257, Article 257
Main Authors: Wang, Tianyi, Zhang, Haijian, Zhou, Youlang, Shi, Jiahai
Format: Article
Language:English
Subjects:
Cancer
Cancer progression
Carcinogenesis
Chromosomes
Circular DNA
Deoxyribonucleic acid
DNA
Extrachromosomal circular DNA
Extrachromosomal DNA
Gene expression
Genetic aspects
Genomes
Genomic instability
Health aspects
Mammals
Mitochondrial DNA
Molecular mechanisms
Nucleotide sequence
Physiological aspects
Research methodology
Researchers
Review
Sperm
Tumors
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Summary:Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles), microDNA, and extrachromosomal DNA (ecDNA) according to its size and sequence. Multiple studies have shown that eccDNA is the product of genomic instability, has rich and important biological functions, and is involved in the occurrence of many diseases, including cancer. In this review, we focus on the discovery history, formation process, characteristics, and physiological functions of eccDNAs; the potential functions of various eccDNAs in human cancer; and the research methods employed to study eccDNA.
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-021-02927-x