The influence of anaesthetic choice on seizure duration of electroconvulsive therapy; etomidate versus methohexital

• Published in: BMC anesthesiology 2022-07, Vol.22 (1), p.1-206, Article 206
• Main Authors: Chomrikh, Laila, Ahmadi, Mustafa, Kuijper, T. Martijn, van der Vlugt, Joris J. B., Koopman, Seppe J. H. A.
• Format: Article
• Language: English
• Subjects: Affective disorder; Affective disorders; Anticonvulsants; Antipsychotics; Convulsions & seizures; Dosage; Drug dosages; Drug use; EEG; Electric currents; Electroconvulsive therapy; Electroencephalography; Etomidate; Medical records; Medical research; Medicine, Experimental; Methohexital; Patients; Preferences; Psychotropic drugs; Seizure duration; Seizures; Variables
• ISSN: 1471-2253; 1471-2253
• DOI: 10.1186/s12871-022-01745-y

Background Many of the anaesthetic drugs used for electroconvulsive therapy have anticonvulsant properties and may influence efficacy of electroconvulsive therapy. With this study we aim to provide more information on the effect of etomidate and methohexital on seizure duration. We explore the relationship between induction drug, motor and electroencephalography seizure duration. Moreover, we study the relationship of seizure duration and number of therapies. Methods In this retrospective study we collected data from patient records from 2005 until 2016. Inclusion criteria were the use of etomidate and/or methohexital and documentation of dosage, electroconvulsive therapy dosage and seizure duration. Exclusion criteria were missing data on either induction drug, dosage or seizure duration. Results Thirty seven patients were analysed. The mean age was 52 years and seventy six percent were female. Most patients were suffering from affective disorders (81%). Motor and electroencephalography seizure duration were analysed in 679 and 551 electroconvulsive therapies, respectively. Compared to methohexital, motor and electroencephalography seizures under etomidate were 7 and 13 s longer, respectively. Furthermore, there was a negative association between seizure duration and number of treatment and a negative association between seizure duration and electroconvulsive therapy dosage. Conclusions This study demonstrates significant longer motor and electroencephalography seizure duration using etomidate compared to methohexital. Etomidate might therefore increase the effectiveness of electroconvulsive therapy. Moreover, we observed a negative association between seizure duration, number of treatment and electroconvulsive therapy dosage. With this study we contribute to the available literature comparing methohexital and etomidate as induction agents for electroconvulsive therapy. Keywords: Electroconvulsive therapy, Affective disorder, Etomidate, Methohexital, Seizure duration