What is the impact of post-COVID-19 syndrome on health-related quality of life and associated factors: a cross-sectional analysis

• Published in: Health and quality of life outcomes 2023-03, Vol.21 (1), p.28-28, Article 28
• Main Authors: Mastrorosa, Ilaria, Del Duca, Giulia, Pinnetti, Carmela, Lorenzini, Patrizia, Vergori, Alessandra, Brita, Anna Clelia, Camici, Marta, Mazzotta, Valentina, Baldini, Francesco, Chinello, Pierangelo, Mencarini, Paola, Giancola, Maria Letizia, Abdeddaim, Amina, Girardi, Enrico, Vaia, Francesco, Antinori, Andrea
• Format: Article
• Language: English
• Subjects: Anxiety; Care and treatment; Comorbidity; Complications; Coronaviruses; Corticoids; Corticosteroids; COVID-19; Cross-Sectional Studies; Diagnosis; Evaluation; Female; Females; Gender; Health aspects; Health-related quality of life; Humans; Infections; Long COVID; Mental depression; Mental health; Neuropsychology; Perceptions; Population; Post-Acute COVID-19 Syndrome; Post-acute sequelae of COVID-19 infection (PASC); Post-COVID-19 condition; Post-COVID-19 syndrome; Prospective Studies; Psychological manifestations of general diseases; Quality of Life; Questionnaires; Ratings; Regression analysis; Regression models; Self image; Severe acute respiratory syndrome coronavirus 2; Signs and symptoms; Sleep disorders; Subgroups; Surveys and Questionnaires; The Short-Form 36-item questionnaire; Viral diseases
• ISSN: 1477-7525; 1477-7525
• DOI: 10.1186/s12955-023-02107-z

After the acute phase, symptoms or sequelae related to post-COVID-19 syndrome may persist for months. In a population of patients, previously hospitalized and not, followed up to 12 months after the acute infection, we aim to assess whether and to what extent post-COVID-19 syndrome may have an impact on health-related quality of life (HRQoL) and to investigate influencing factors. We present the cross-sectional analysis of a prospective study, including patients referred to the post-COVID-19 service. Questionnaires and scales administered at 3, 6, 12 months were: Short-Form 36-item questionnaire (SF-36); Visual Analogue Scale of the EQ5D (EQ-VAS); in a subgroup, Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI-II) and Pittsburgh Sleep Quality Index (PSQI). Linear regression models were fitted to identify factors associated with HRQoL. We considered the first assessment of each participant (n = 572). The mean scores in SF-36 and in EQ-VAS were significantly lower than the Italian normative values and remained stable over time, except the mental components score (MCS) of the SF-36 and EQ-VAS which resulted in lower ratings at the last observations. Female gender, presence of comorbidities, and corticosteroids treatment during acute COVID-19, were associated with lower scores in SF-36 and EQ-VAS; patients previously hospitalized (54%) reported higher MCS. Alterations in BAI, BDI-II, and PSQI (n = 265)were associated with lower ratings in SF-36 and EQ-VAS. This study provides evidence of a significantly bad perception of health status among persons with post-COVID-19 syndrome, associated with female gender and, indirectly, with disease severity. In case of anxious-depressive symptoms and sleep disorders, a worse HRQoL was also reported. A systematic monitoring of these aspects is recommended to properly manage the post-COVID-19 period.