Dynamics of Vascular Protective and Immune Supportive Sphingosine-1-Phosphate During Cardiac Surgery

Sphingosine-1-phosphate (S1P) is a signaling lipid and crucial in vascular protection and immune response. S1P mediated processes involve regulation of the endothelial barrier, blood pressure and S1P is the only known inducer of lymphocyte migration. Low levels of circulatory S1P correlate with seve...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2021-10, Vol.12, p.761475-761475
Main Authors: Greiwe, Gillis, Moritz, Eileen, Amschler, Katharina, Poppe, Annika, Sarwari, Harun, Nierhaus, Axel, Kluge, Stefan, Reichenspurner, Hermann, Zoellner, Christian, Schwedhelm, Edzard, Daum, Günter, Tampe, Björn, Winkler, Martin Sebastian
Format: Article
Language:English
Subjects:
Aged
cardiac surgery
Cardiac Surgical Procedures
Female
heparin
Humans
Immunology
Inflammation - blood
Intensive Care Units
Length of Stay
Lysophospholipids - blood
Male
Middle Aged
Prospective Studies
sepsis
SIRS
Sphingosine - analogs & derivatives
Sphingosine - blood
sphingosine-1-phosphate
systemic inflammation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sphingosine-1-phosphate (S1P) is a signaling lipid and crucial in vascular protection and immune response. S1P mediated processes involve regulation of the endothelial barrier, blood pressure and S1P is the only known inducer of lymphocyte migration. Low levels of circulatory S1P correlate with severe systemic inflammatory syndromes such as sepsis and shock states, which are associated with endothelial barrier breakdown and immunosuppression. We investigated whether S1P levels are affected by sterile inflammation induced by cardiac surgery. In this prospective observational study we included 46 cardiac surgery patients, with cardiopulmonary bypass (CPB, n=31) and without CPB (off-pump, n=15). Serum-S1P, S1P-sources and carriers, von-Willebrand factor (vWF), C-reactive protein (CRP), procalcitonin (PCT) and interleukin-6 (IL-6) were measured at baseline, post-surgery and at day 1 (POD 1) and day 4 (POD 4) after surgical stimulus. Median S1P levels at baseline were 0.77 nmol/mL (IQR 0.61-0.99) and dropped significantly post-surgery. S1P was lowest post-surgery with median levels of 0.37 nmol/mL (IQR 0.31-0.47) after CPB and 0.46 nmol/mL (IQR 0.36-0.51) after off-pump procedures (P
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.761475