Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica

Two types of mesoporous materials, MCM-41 and MCM-48, were functionalized by the soft-template method using (3-aminopropyl)triethoxysilane (APTES) as a modifying agent. The obtained mesoporous silica materials were loaded with trans-ferulic acid (FA). In order to establish the morphology and structu...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics 2023-02, Vol.15 (2), p.660
Main Authors: Petrișor, Gabriela, Motelica, Ludmila, Ficai, Denisa, Ilie, Cornelia-Ioana, Trușcǎ, Roxana Doina, Surdu, Vasile-Adrian, Oprea, Ovidiu-Cristian, Mȋrț, Andreea-Luiza, Vasilievici, Gabriel, Semenescu, Augustin, Ficai, Anton, Dițu, Lia-Mara
Format: Article
Language:English
Subjects:
(3-aminopropyl)triethoxysilane
Antibiotics
antimicrobial activity
Antimicrobial agents
Antioxidants
Bioavailability
Biological activity
Chronic illnesses
controlled release
Drug delivery systems
Drugs
Evaluation
Fruits
Materials
mesoporous silica
Morphology
Nanoparticles
Polyphenols
Radiation
Silica
Spectrum analysis
trans-ferulic acid
Vehicles
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two types of mesoporous materials, MCM-41 and MCM-48, were functionalized by the soft-template method using (3-aminopropyl)triethoxysilane (APTES) as a modifying agent. The obtained mesoporous silica materials were loaded with trans-ferulic acid (FA). In order to establish the morphology and structure of mesoporous materials, a series of specific techniques were used such as: X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer-Emmet-Teller (BET), Fourier Transform Infrared Spectroscopy (FTIR) and thermogravimetric analysis (TGA). We monitored the in vitro release of the loaded FA at two different pH values, by using simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Additionally, ATCC 25923, ATCC 25922, ATCC 27853 and ATCC 10231 were used to evaluate the antimicrobial activity of FA loaded mesoporous silica materials. In conclusion such functionalized mesoporous materials can be employed as controlled release systems for polyphenols extracted from natural sources.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15020660