Loading…
Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica
Two types of mesoporous materials, MCM-41 and MCM-48, were functionalized by the soft-template method using (3-aminopropyl)triethoxysilane (APTES) as a modifying agent. The obtained mesoporous silica materials were loaded with trans-ferulic acid (FA). In order to establish the morphology and structu...
Saved in:
| Published in: | Pharmaceutics 2023-02, Vol.15 (2), p.660 |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c572t-5c522d8588383e866bd3e2ea42fa31f7e80ec235df950a2fd494bd34848542d3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c572t-5c522d8588383e866bd3e2ea42fa31f7e80ec235df950a2fd494bd34848542d3 |
| container_end_page | |
| container_issue | 2 |
| container_start_page | 660 |
| container_title | Pharmaceutics |
| container_volume | 15 |
| creator | Petrișor, Gabriela Motelica, Ludmila Ficai, Denisa Ilie, Cornelia-Ioana Trușcǎ, Roxana Doina Surdu, Vasile-Adrian Oprea, Ovidiu-Cristian Mȋrț, Andreea-Luiza Vasilievici, Gabriel Semenescu, Augustin Ficai, Anton Dițu, Lia-Mara |
| description | Two types of mesoporous materials, MCM-41 and MCM-48, were functionalized by the soft-template method using (3-aminopropyl)triethoxysilane (APTES) as a modifying agent. The obtained mesoporous silica materials were loaded with trans-ferulic acid (FA). In order to establish the morphology and structure of mesoporous materials, a series of specific techniques were used such as: X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer-Emmet-Teller (BET), Fourier Transform Infrared Spectroscopy (FTIR) and thermogravimetric analysis (TGA). We monitored the in vitro release of the loaded FA at two different pH values, by using simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Additionally,
ATCC 25923,
ATCC 25922,
ATCC 27853 and
ATCC 10231 were used to evaluate the antimicrobial activity of FA loaded mesoporous silica materials. In conclusion such functionalized mesoporous materials can be employed as controlled release systems for polyphenols extracted from natural sources. |
| doi_str_mv | 10.3390/pharmaceutics15020660 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_e9537ad9998a4e12bb902126bdb6c325</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A743326657</galeid><doaj_id>oai_doaj_org_article_e9537ad9998a4e12bb902126bdb6c325</doaj_id><sourcerecordid>A743326657</sourcerecordid><originalsourceid>FETCH-LOGICAL-c572t-5c522d8588383e866bd3e2ea42fa31f7e80ec235df950a2fd494bd34848542d3</originalsourceid><addsrcrecordid>eNptUsFu1DAQjRCIVqWfAIrEhcsWx44d-4K0VF1YqYgDe7cm9mTrVWIHO6m0fD1etpQuqn2Y0fi9N5rnKYq3FbliTJGP4x3EAQzOkzOp4oQSIciL4rxSSi1qRdnLJ_lZcZnSjuTDWCWZel2cMZGjkvS8wLU3ESE5vy0_uwD34HpoXe-mfRm6chPBp8UK49w7Uy6Ns2W7L2-8gTHNPUwu-NL5cjV7c8ihd7_Qlt8whTHEMKfyR5Yy8KZ41UGf8PIhXhSb1c3m-uvi9vuX9fXydmF4Q6cFN5xSK7mUTDKUQrSWIUWoaQes6hqUBA1l3HaKE6CdrVWdIbWsJa-pZRfF-ihrA-z0GN0Aca8DOP2nEOJWQ8yW9ahRcdaAzR5JqLGibasIrWju2ArDKM9an45a49wOaA36KUJ_Inr64t2d3oZ7rZSQpKmywIcHgRh-zpgmPbhksO_BY3ZG00aS_G1Uigx9_x90F-aY3TygGiV4pRj5h9pCHsD5LuS-5iCql03NGBWCNxl19QwqX4uDM8Fj53L9hMCPBBNDShG7xxkrog_bpp_dtsx799SgR9bf3WK_ASUu08o</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2779651930</pqid></control><display><type>article</type><title>Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica</title><source>NCBI_PubMed Central（免费）</source><source>Publicly Available Content Database</source><creator>Petrișor, Gabriela ; Motelica, Ludmila ; Ficai, Denisa ; Ilie, Cornelia-Ioana ; Trușcǎ, Roxana Doina ; Surdu, Vasile-Adrian ; Oprea, Ovidiu-Cristian ; Mȋrț, Andreea-Luiza ; Vasilievici, Gabriel ; Semenescu, Augustin ; Ficai, Anton ; Dițu, Lia-Mara</creator><creatorcontrib>Petrișor, Gabriela ; Motelica, Ludmila ; Ficai, Denisa ; Ilie, Cornelia-Ioana ; Trușcǎ, Roxana Doina ; Surdu, Vasile-Adrian ; Oprea, Ovidiu-Cristian ; Mȋrț, Andreea-Luiza ; Vasilievici, Gabriel ; Semenescu, Augustin ; Ficai, Anton ; Dițu, Lia-Mara</creatorcontrib><description>Two types of mesoporous materials, MCM-41 and MCM-48, were functionalized by the soft-template method using (3-aminopropyl)triethoxysilane (APTES) as a modifying agent. The obtained mesoporous silica materials were loaded with trans-ferulic acid (FA). In order to establish the morphology and structure of mesoporous materials, a series of specific techniques were used such as: X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer-Emmet-Teller (BET), Fourier Transform Infrared Spectroscopy (FTIR) and thermogravimetric analysis (TGA). We monitored the in vitro release of the loaded FA at two different pH values, by using simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Additionally,
ATCC 25923,
ATCC 25922,
ATCC 27853 and
ATCC 10231 were used to evaluate the antimicrobial activity of FA loaded mesoporous silica materials. In conclusion such functionalized mesoporous materials can be employed as controlled release systems for polyphenols extracted from natural sources.</description><identifier>ISSN: 1999-4923</identifier><identifier>EISSN: 1999-4923</identifier><identifier>DOI: 10.3390/pharmaceutics15020660</identifier><identifier>PMID: 36839982</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>(3-aminopropyl)triethoxysilane ; Antibiotics ; antimicrobial activity ; Antimicrobial agents ; Antioxidants ; Bioavailability ; Biological activity ; Chronic illnesses ; controlled release ; Drug delivery systems ; Drugs ; Evaluation ; Fruits ; Materials ; mesoporous silica ; Morphology ; Nanoparticles ; Polyphenols ; Radiation ; Silica ; Spectrum analysis ; trans-ferulic acid ; Vehicles</subject><ispartof>Pharmaceutics, 2023-02, Vol.15 (2), p.660</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-5c522d8588383e866bd3e2ea42fa31f7e80ec235df950a2fd494bd34848542d3</citedby><cites>FETCH-LOGICAL-c572t-5c522d8588383e866bd3e2ea42fa31f7e80ec235df950a2fd494bd34848542d3</cites><orcidid>0000-0002-3371-4136 ; 0000-0001-6864-3297 ; 0000-0003-1243-6904 ; 0000-0002-8145-1094 ; 0000-0002-4207-5380 ; 0000-0002-0217-929X ; 0000-0002-5504-5156 ; 0000-0002-1777-0525 ; 0000-0003-0766-9068</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2779651930/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2779651930?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36839982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petrișor, Gabriela</creatorcontrib><creatorcontrib>Motelica, Ludmila</creatorcontrib><creatorcontrib>Ficai, Denisa</creatorcontrib><creatorcontrib>Ilie, Cornelia-Ioana</creatorcontrib><creatorcontrib>Trușcǎ, Roxana Doina</creatorcontrib><creatorcontrib>Surdu, Vasile-Adrian</creatorcontrib><creatorcontrib>Oprea, Ovidiu-Cristian</creatorcontrib><creatorcontrib>Mȋrț, Andreea-Luiza</creatorcontrib><creatorcontrib>Vasilievici, Gabriel</creatorcontrib><creatorcontrib>Semenescu, Augustin</creatorcontrib><creatorcontrib>Ficai, Anton</creatorcontrib><creatorcontrib>Dițu, Lia-Mara</creatorcontrib><title>Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica</title><title>Pharmaceutics</title><addtitle>Pharmaceutics</addtitle><description>Two types of mesoporous materials, MCM-41 and MCM-48, were functionalized by the soft-template method using (3-aminopropyl)triethoxysilane (APTES) as a modifying agent. The obtained mesoporous silica materials were loaded with trans-ferulic acid (FA). In order to establish the morphology and structure of mesoporous materials, a series of specific techniques were used such as: X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer-Emmet-Teller (BET), Fourier Transform Infrared Spectroscopy (FTIR) and thermogravimetric analysis (TGA). We monitored the in vitro release of the loaded FA at two different pH values, by using simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Additionally,
ATCC 25923,
ATCC 25922,
ATCC 27853 and
ATCC 10231 were used to evaluate the antimicrobial activity of FA loaded mesoporous silica materials. In conclusion such functionalized mesoporous materials can be employed as controlled release systems for polyphenols extracted from natural sources.</description><subject>(3-aminopropyl)triethoxysilane</subject><subject>Antibiotics</subject><subject>antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Antioxidants</subject><subject>Bioavailability</subject><subject>Biological activity</subject><subject>Chronic illnesses</subject><subject>controlled release</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Evaluation</subject><subject>Fruits</subject><subject>Materials</subject><subject>mesoporous silica</subject><subject>Morphology</subject><subject>Nanoparticles</subject><subject>Polyphenols</subject><subject>Radiation</subject><subject>Silica</subject><subject>Spectrum analysis</subject><subject>trans-ferulic acid</subject><subject>Vehicles</subject><issn>1999-4923</issn><issn>1999-4923</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUsFu1DAQjRCIVqWfAIrEhcsWx44d-4K0VF1YqYgDe7cm9mTrVWIHO6m0fD1etpQuqn2Y0fi9N5rnKYq3FbliTJGP4x3EAQzOkzOp4oQSIciL4rxSSi1qRdnLJ_lZcZnSjuTDWCWZel2cMZGjkvS8wLU3ESE5vy0_uwD34HpoXe-mfRm6chPBp8UK49w7Uy6Ns2W7L2-8gTHNPUwu-NL5cjV7c8ihd7_Qlt8whTHEMKfyR5Yy8KZ41UGf8PIhXhSb1c3m-uvi9vuX9fXydmF4Q6cFN5xSK7mUTDKUQrSWIUWoaQes6hqUBA1l3HaKE6CdrVWdIbWsJa-pZRfF-ihrA-z0GN0Aca8DOP2nEOJWQ8yW9ahRcdaAzR5JqLGibasIrWju2ArDKM9an45a49wOaA36KUJ_Inr64t2d3oZ7rZSQpKmywIcHgRh-zpgmPbhksO_BY3ZG00aS_G1Uigx9_x90F-aY3TygGiV4pRj5h9pCHsD5LuS-5iCql03NGBWCNxl19QwqX4uDM8Fj53L9hMCPBBNDShG7xxkrog_bpp_dtsx799SgR9bf3WK_ASUu08o</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Petrișor, Gabriela</creator><creator>Motelica, Ludmila</creator><creator>Ficai, Denisa</creator><creator>Ilie, Cornelia-Ioana</creator><creator>Trușcǎ, Roxana Doina</creator><creator>Surdu, Vasile-Adrian</creator><creator>Oprea, Ovidiu-Cristian</creator><creator>Mȋrț, Andreea-Luiza</creator><creator>Vasilievici, Gabriel</creator><creator>Semenescu, Augustin</creator><creator>Ficai, Anton</creator><creator>Dițu, Lia-Mara</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3371-4136</orcidid><orcidid>https://orcid.org/0000-0001-6864-3297</orcidid><orcidid>https://orcid.org/0000-0003-1243-6904</orcidid><orcidid>https://orcid.org/0000-0002-8145-1094</orcidid><orcidid>https://orcid.org/0000-0002-4207-5380</orcidid><orcidid>https://orcid.org/0000-0002-0217-929X</orcidid><orcidid>https://orcid.org/0000-0002-5504-5156</orcidid><orcidid>https://orcid.org/0000-0002-1777-0525</orcidid><orcidid>https://orcid.org/0000-0003-0766-9068</orcidid></search><sort><creationdate>20230201</creationdate><title>Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica</title><author>Petrișor, Gabriela ; Motelica, Ludmila ; Ficai, Denisa ; Ilie, Cornelia-Ioana ; Trușcǎ, Roxana Doina ; Surdu, Vasile-Adrian ; Oprea, Ovidiu-Cristian ; Mȋrț, Andreea-Luiza ; Vasilievici, Gabriel ; Semenescu, Augustin ; Ficai, Anton ; Dițu, Lia-Mara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-5c522d8588383e866bd3e2ea42fa31f7e80ec235df950a2fd494bd34848542d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>(3-aminopropyl)triethoxysilane</topic><topic>Antibiotics</topic><topic>antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>Antioxidants</topic><topic>Bioavailability</topic><topic>Biological activity</topic><topic>Chronic illnesses</topic><topic>controlled release</topic><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>Evaluation</topic><topic>Fruits</topic><topic>Materials</topic><topic>mesoporous silica</topic><topic>Morphology</topic><topic>Nanoparticles</topic><topic>Polyphenols</topic><topic>Radiation</topic><topic>Silica</topic><topic>Spectrum analysis</topic><topic>trans-ferulic acid</topic><topic>Vehicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petrișor, Gabriela</creatorcontrib><creatorcontrib>Motelica, Ludmila</creatorcontrib><creatorcontrib>Ficai, Denisa</creatorcontrib><creatorcontrib>Ilie, Cornelia-Ioana</creatorcontrib><creatorcontrib>Trușcǎ, Roxana Doina</creatorcontrib><creatorcontrib>Surdu, Vasile-Adrian</creatorcontrib><creatorcontrib>Oprea, Ovidiu-Cristian</creatorcontrib><creatorcontrib>Mȋrț, Andreea-Luiza</creatorcontrib><creatorcontrib>Vasilievici, Gabriel</creatorcontrib><creatorcontrib>Semenescu, Augustin</creatorcontrib><creatorcontrib>Ficai, Anton</creatorcontrib><creatorcontrib>Dițu, Lia-Mara</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Proquest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petrișor, Gabriela</au><au>Motelica, Ludmila</au><au>Ficai, Denisa</au><au>Ilie, Cornelia-Ioana</au><au>Trușcǎ, Roxana Doina</au><au>Surdu, Vasile-Adrian</au><au>Oprea, Ovidiu-Cristian</au><au>Mȋrț, Andreea-Luiza</au><au>Vasilievici, Gabriel</au><au>Semenescu, Augustin</au><au>Ficai, Anton</au><au>Dițu, Lia-Mara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica</atitle><jtitle>Pharmaceutics</jtitle><addtitle>Pharmaceutics</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>15</volume><issue>2</issue><spage>660</spage><pages>660-</pages><issn>1999-4923</issn><eissn>1999-4923</eissn><abstract>Two types of mesoporous materials, MCM-41 and MCM-48, were functionalized by the soft-template method using (3-aminopropyl)triethoxysilane (APTES) as a modifying agent. The obtained mesoporous silica materials were loaded with trans-ferulic acid (FA). In order to establish the morphology and structure of mesoporous materials, a series of specific techniques were used such as: X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer-Emmet-Teller (BET), Fourier Transform Infrared Spectroscopy (FTIR) and thermogravimetric analysis (TGA). We monitored the in vitro release of the loaded FA at two different pH values, by using simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Additionally,
ATCC 25923,
ATCC 25922,
ATCC 27853 and
ATCC 10231 were used to evaluate the antimicrobial activity of FA loaded mesoporous silica materials. In conclusion such functionalized mesoporous materials can be employed as controlled release systems for polyphenols extracted from natural sources.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36839982</pmid><doi>10.3390/pharmaceutics15020660</doi><orcidid>https://orcid.org/0000-0002-3371-4136</orcidid><orcidid>https://orcid.org/0000-0001-6864-3297</orcidid><orcidid>https://orcid.org/0000-0003-1243-6904</orcidid><orcidid>https://orcid.org/0000-0002-8145-1094</orcidid><orcidid>https://orcid.org/0000-0002-4207-5380</orcidid><orcidid>https://orcid.org/0000-0002-0217-929X</orcidid><orcidid>https://orcid.org/0000-0002-5504-5156</orcidid><orcidid>https://orcid.org/0000-0002-1777-0525</orcidid><orcidid>https://orcid.org/0000-0003-0766-9068</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1999-4923 |
| ispartof | Pharmaceutics, 2023-02, Vol.15 (2), p.660 |
| issn | 1999-4923 1999-4923 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_e9537ad9998a4e12bb902126bdb6c325 |
| source | NCBI_PubMed Central（免费）; Publicly Available Content Database |
| subjects | (3-aminopropyl)triethoxysilane Antibiotics antimicrobial activity Antimicrobial agents Antioxidants Bioavailability Biological activity Chronic illnesses controlled release Drug delivery systems Drugs Evaluation Fruits Materials mesoporous silica Morphology Nanoparticles Polyphenols Radiation Silica Spectrum analysis trans-ferulic acid Vehicles |
| title | Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T07%3A24%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increasing%20Bioavailability%20of%20Trans-Ferulic%20Acid%20by%20Encapsulation%20in%20Functionalized%20Mesoporous%20Silica&rft.jtitle=Pharmaceutics&rft.au=Petri%C8%99or,%20Gabriela&rft.date=2023-02-01&rft.volume=15&rft.issue=2&rft.spage=660&rft.pages=660-&rft.issn=1999-4923&rft.eissn=1999-4923&rft_id=info:doi/10.3390/pharmaceutics15020660&rft_dat=%3Cgale_doaj_%3EA743326657%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c572t-5c522d8588383e866bd3e2ea42fa31f7e80ec235df950a2fd494bd34848542d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2779651930&rft_id=info:pmid/36839982&rft_galeid=A743326657&rfr_iscdi=true |